Hepatocyte Elovl6 determines ceramide acyl‐chain length and hepatic insulin sensitivity in mice,Hepatology

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Hepatocyte Elovl6 determines ceramide acyl‐chain length and hepatic insulin sensitivity in mice
Hepatology ( IF 12.9 ) Pub Date : 2020-02-07 , DOI: 10.1002/hep.30953
Takashi Matsuzaka _{1,

2} , Motoko Kuba ₁ , Saori Koyasu ₁ , Yuta Yamamoto ₃ , Kaori Motomura ₁ , Sundaram Arulmozhiraja ₃ , Hiroshi Ohno ₁ , Rahul Sharma ₁ , Takuya Shimura ₁ , Yuka Okajima ₁ , Song-Iee Han ₁ , Yuichi Aita ₁ , Yuhei Mizunoe ₁ , Yoshinori Osaki ₁ , Hitoshi Iwasaki ₁ , Shigeru Yatoh ₁ , Hiroaki Suzuki ₁ , Hirohito Sone ₄ , Yoshinori Takeuchi ₁ , Naoya Yahagi ₁ , Takafumi Miyamoto _{1,

2} , Motohiro Sekiya ₁ , Yoshimi Nakagawa _{1,

5} , Masatsugu Ema ₆ , Satoru Takahashi _{2,

5,

7,

8,

9} , Hiroaki Tokiwa ₃ , Hitoshi Shimano _{1,

5,

8,

10}

Affiliation

Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Transborder Medical Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Department of Chemistry, Rikkyo University, Toshima, Tokyo, Japan.
Department of Internal Medicine, Faculty of Medicine, Niigata University, Niigata, Japan.
International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga, Japan.
Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Laboratory Animal Resource Center, University of Tsukuba, Tsukuba, Ibaraki, Japan.
AMED-CREST, Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo, Japan.

Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder worldwide, and is closely associated with insulin resistance and type 2 diabetes. ELOVL fatty acid elongase 6 (Elovl6) is responsible for converting C16 saturated and monounsaturated fatty acids (FAs) into C18 species. We have previously shown that Elovl6 contributes to obesity‐induced insulin resistance by modifying hepatic C16/C18‐related FA composition.

中文翻译：

肝细胞 Elovl6 决定小鼠神经酰胺酰基链长度和肝脏胰岛素敏感性

功能失调的肝脏脂质代谢是非酒精性脂肪性肝病 (NAFLD) 的一个原因，NAFLD 是全球最常见的慢性肝病，并且与胰岛素抵抗和 2 型糖尿病密切相关。ELOVL 脂肪酸延长酶 6 (Elovl6) 负责将 C16 饱和和单不饱和脂肪酸 (FA) 转化为 C18 种类。我们之前已经表明，Elovl6 通过改变肝脏 C16/C18 相关的 FA 组成来促进肥胖诱导的胰岛素抵抗。

更新日期：2020-02-07

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