The lipid-derived hormones jasmonates (JAs) play key functions in a wide range of physiological and developmental processes that regulate growth, secondary metabolism and defense against biotic and abiotic stresses. In this connection, biosynthesis, tissue-specific distribution, metabolism, perception, signaling of JAs have been the target of extensive studies. In recent years, the involvement of JAs signaling pathway in the regulation of growth and adaptive responses to environmental challenges has been further examined. However, JAs-mediated mechanisms underlying the transition from 'growth mode' to 'adaptive mode' remain ambiguous. Combined analysis of transgenic lines deficient in JAs signaling in conjunction with the data from JAs-treated plants revealed the function of these hormones in rewiring of central metabolism. The collective data illustrate JAs-mediated decrease in the levels of metabolites associated with active growth such as sucrose, raffinose, orotate, citrate, malate, and an increase in phosphorylated hexoses, responsible for the suppression of growth and photosynthesis, concurrent with the induction of protective metabolites, such as aromatic and branched-chain amino acids, and aspartate family of metabolites. This finding provides an insight into the function of JAs in shifting the central metabolism from the production of growth-promoting metabolites to protective compounds and expands our understanding of the role of JAs in resource allocation in response to environmental challenges.

中文翻译：

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茉莉酸介导的中枢代谢的重新连接调节适应性反应。

脂类激素茉莉酸酯（JAs）在广泛的生理和发育过程中起关键作用，这些过程调节生长，次级代谢和防御生物和非生物胁迫。在这方面，JA的生物合成，组织特异性分布，代谢，知觉，信号传导已成为广泛研究的目标。近年来，JAs信号通路在调节生长和对环境挑战的适应性反应中的参与已得到进一步研究。但是，JAs介导的从“增长模式”到“自适应模式”过渡的机制仍然是模棱两可的。对JAs信号不足的转基因品系的综合分析与来自JAs处理过的植物的数据相结合，揭示了这些激素在中枢代谢重新布线中的功能。收集的数据表明，JAs介导的与活性生长相关的代谢物水平降低，例如蔗糖，棉子糖，乳清酸盐，柠檬酸盐，苹果酸，以及磷酸化己糖的增加，这导致了生长和光合作用的抑制，同时诱导了果糖的生长。保护性代谢物，例如芳香族和支链氨基酸，以及天冬氨酸家族的代谢产物。该发现提供了对JAs在将中心代谢从促进生长的代谢产物的产生转移到保护性化合物中的功能的见解，并扩展了我们对JAs在应对环境挑战中在资源分配中的作用的理解。导致抑制生长和光合作用的磷酸化己糖的增加，同时诱导保护性代谢产物（如芳香族和支链氨基酸）和天冬氨酸家族的代谢。该发现提供了对JAs在将中心代谢从促进生长的代谢产物的产生转移到保护性化合物中的功能的见解，并扩展了我们对JAs在应对环境挑战中在资源分配中的作用的理解。导致抑制生长和光合作用的磷酸化己糖的增加，同时诱导保护性代谢产物（如芳香族和支链氨基酸）和天冬氨酸家族的代谢。该发现提供了对JAs在将中心代谢从促进生长的代谢产物的产生转移到保护性化合物中的功能的见解，并扩展了我们对JAs在应对环境挑战中在资源分配中的作用的理解。