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Leptin boosts T cell function in tumours.
Nature Reviews Cancer ( IF 78.5 ) Pub Date : 2019-11-01 , DOI: 10.1038/s41568-019-0208-7
Ulrike Harjes 1
Affiliation  

Rivadeneira et al. show that treatment of melanoma-bearing mice with the oncolytic Vaccinia virus recruits metabolically dysfunctional CD8+ T cells, which limits tumour regression. Vaccinia-mediated engineered expression of leptin in cancer cells…

中文翻译:

瘦素可增强肿瘤中的 T 细胞功能。

里瓦德内拉等人。表明用溶瘤牛痘病毒治疗黑色素瘤小鼠会募集代谢功能失调的 CD8+ T 细胞,从而限制肿瘤消退。牛痘介导的瘦素在癌细胞中的工程化表达……
更新日期:2019-09-16
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