Evaluation of glomerular filtration rate (GFR) is central to the assessment of kidney function in medical practice, research and public health. Measured GFR (mGFR) remains the reference standard, but the past 20 years have seen major advances in estimated GFR (eGFR). Both eGFR and mGFR are associated with error compared with true GFR. eGFR is now recommended by clinical practice guidelines, regulatory agencies and public health agencies for the initial evaluation of GFR, with measured GFR (mGFR) typically considered an important confirmatory test, depending on how accurate the assessment of GFR needs to be for application to the clinical, research or public health setting. Our approach is to use initial and confirmatory tests as needed to develop a final assessment of true GFR. We suggest that GFR evaluation might be improved by more complete implementation of current recommendations and by further research to improve the accuracy of mGFR and eGFR.

肾小球滤过率 (GFR) 的评估是医疗实践、研究和公共卫生中评估肾功能的核心。测量的 GFR (mGFR) 仍然是参考标准，但过去 20 年在估计的 GFR (eGFR) 方面取得了重大进展。与真实 GFR 相比，eGFR 和 mGFR 都与误差相关。eGFR 现在被临床实践指南、监管机构和公共卫生机构推荐用于 GFR 的初步评估，测量的 GFR (mGFR) 通常被认为是一项重要的确认测试，具体取决于 GFR 评估的准确度需要如何应用于临床、研究或公共卫生环境。我们的方法是根据需要使用初始和确认性测试来对真实 GFR 进行最终评估。