Paneth cell dysfunction mediates alcoholic steatohepatitis through promoting bacterial translocation in mice: role of zinc deficiency,Hepatology

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Paneth cell dysfunction mediates alcoholic steatohepatitis through promoting bacterial translocation in mice: role of zinc deficiency
Hepatology ( IF 12.9 ) Pub Date : 2020-03-10 , DOI: 10.1002/hep.30945
Wei Zhong _{1,

2} , Xiaoyuan Wei ₃ , Liuyi Hao ₁ , Tai-Du Lin _{1,

4} , Ruichao Yue ₁ , Xinguo Sun ₁ , Wei Guo ₁ , Haibo Dong ₁ , Tianjiao Li ₂ , Ali R Ahmadi ₅ , Zhaoli Sun ₅ , Qibin Zhang _{1,

4} , Jiangchao Zhao ₃ , Zhanxiang Zhou _{1,

2}

Affiliation

Microbial dysbiosis is associated with alcohol‐related hepatitis (AH), with the mechanisms yet to be elucidated. The present study aimed to determine the effects of alcohol and zinc deficiency on Paneth cell (PC) antimicrobial peptides, α‐defensins, and to define the link between PC dysfunction and AH.

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