The study deals with the development of selective sorbents that are able to remove viral particles, particularly the hepatitis B surface antigen (HBsAg), from blood serum of patients infected with hepatitis B virus (HBV). The hemosorbents were obtained by modification with gas-phase fluorine and BrF₃ solutions in HF and subsequent substitution of fluorine by amino groups. Polyalbumin (PA) (human serum albumin (HSA) modified with glutaraldehyde) was synthesized and then used as a bioligand. To ensure a strong fixing, polyalbumin was covalently bound to fluorocarbon hemosorbents (FH) with amino groups. The immobilized polyalbumin selectively interacts with the hepatitis B surface antigen receptor. Properties of the produced hemosorbent samples were studied using various physicochemical methods: scanning electron microscopy, X-ray microanalysis, IR spectroscopy, X-ray photoelectron spectroscopy, and others. Blood serum samples positive for HBV DNA and HBsAg were examined to separate viruses by the synthesized hemosorbents. The carbon hemosorbent fluorinated with BrF₃ solutions in HF and having immobilized polyalbumin was found to be the most efficient one.

该研究涉及选择性吸附剂的开发，该吸附剂能够从感染了乙型肝炎病毒（HBV）的患者的血清中去除病毒颗粒，特别是乙型肝炎表面抗原（HBsAg）。通过气相氟和BrF ₃改性获得吸血剂在HF中溶解，随后用氨基取代氟。合成了聚白蛋白（PA）（戊二醛修饰的人血清白蛋白（HSA）），然后用作生物配体。为了确保牢固固定，将聚白蛋白与具有氨基的碳氟化合物吸血剂（FH）共价结合。固定的白蛋白选择性地与乙型肝炎表面抗原受体相互作用。使用各种物理化学方法研究了产生的吸血剂样品的特性：扫描电子显微镜，X射线显微分析，IR光谱，X射线光电子能谱等。通过合成的吸血剂检查了HBV DNA和HBsAg阳性的血清样本，以分离出病毒。BrF ₃氟化的碳吸血剂 HF中的溶液和固定化的白蛋白被认为是最有效的溶液。