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Atomic force microscopy-based single-molecule force spectroscopy detects DNA base mismatches.
Nanoscale ( IF 5.8 ) Pub Date : 2019-09-17 , DOI: 10.1039/c9nr05234h Wenjing Liu 1 , Yourong Guo 2 , Kaizhe Wang 1 , Xingfei Zhou 3 , Ying Wang 4 , Junhong Lü 4 , Zhifeng Shao 2 , Jun Hu 5 , Daniel M Czajkowsky 2 , Bin Li 4
Nanoscale ( IF 5.8 ) Pub Date : 2019-09-17 , DOI: 10.1039/c9nr05234h Wenjing Liu 1 , Yourong Guo 2 , Kaizhe Wang 1 , Xingfei Zhou 3 , Ying Wang 4 , Junhong Lü 4 , Zhifeng Shao 2 , Jun Hu 5 , Daniel M Czajkowsky 2 , Bin Li 4
Affiliation
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Atomic force microscopy-based single-molecule-force spectroscopy is limited by low throughput. We introduce addressable DNA origami to study multiple target molecules. Six target DNAs that differed by only a single base-pair mismatch were clearly differentiated a rupture force of only 4 pN.
中文翻译：
基于原子力显微镜的单分子力光谱检测DNA碱基不匹配。
低通量限制了基于原子力显微镜的单分子力光谱学。我们引入可寻址的DNA折纸来研究多个目标分子。六个仅相差一个碱基对错配的靶标DNA的断裂力就明显不同，仅为4 pN。
更新日期：2019-09-26
中文翻译：
基于原子力显微镜的单分子力光谱检测DNA碱基不匹配。
低通量限制了基于原子力显微镜的单分子力光谱学。我们引入可寻址的DNA折纸来研究多个目标分子。六个仅相差一个碱基对错配的靶标DNA的断裂力就明显不同，仅为4 pN。
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