Hormesis in Health and Chronic Diseases,Trends in Endocrinology & Metabolism

当前位置： X-MOL 学术 › Trends Endocrin. Met. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Hormesis in Health and Chronic Diseases
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2019-12-01 , DOI: 10.1016/j.tem.2019.08.007
Xin Li ₁ , Tingting Yang ₂ , Zheng Sun ₃

Affiliation

'What doesn't kill you makes you stronger'. Hormesis, the paradoxical beneficial effects of low-dose stressors, can be better defined as the biphasic dose-effect or time-effect relationship for any substance. Here we review hormesis-like phenomena in the context of chronic diseases for many substances, including lifestyle factors and endocrine factors. Intermittent or pulsatile exposure can generate opposite effects compared with continuous exposure. An initial exposure can elicit an adaptive stress response with long-lasting protection against subsequent exposures. Early-life stress can increase resilience in later life and lack of stress can lead to vulnerability. Many stressors are naturally occurring and are required for healthy growth or homeostasis, which exemplifies how 'illness is the doorway to health'.

中文翻译：

健康和慢性疾病中的毒物兴奋作用

“那些杀不死你的，都会让你变得更强大”。毒物兴奋效应，即低剂量应激源的矛盾有益作用，可以更好地定义为任何物质的双相剂量效应或时间效应关系。在这里，我们回顾了许多物质在慢性疾病背景下的毒物兴奋效应样现象，包括生活方式因素和内分泌因素。与连续暴露相比，间歇或脉冲暴露会产生相反的效果。初次接触可以引发适应性应激反应，并针对后续接触提供持久的保护。早年的压力可以提高晚年生活的适应能力，而缺乏压力会导致脆弱。许多压力源是自然发生的，是健康成长或体内平衡所必需的，这说明了“疾病是健康的大门”。

更新日期：2019-12-01

点击分享查看原文

点击收藏

阅读更多本刊最新论文