Monoacylglycerol lipase (MGL) is the last enzymatic step in triglyceride degradation, hydrolyzing monoglycerides into glycerol and fatty acids (FAs) and converting 2‐arachidonoylglycerol into arachidonic acid, thus providing ligands for nuclear receptors as key regulators of hepatic bile acid (BA)/lipid metabolism and inflammation. We aimed to explore the role of MGL in the development of cholestatic liver and bile duct injury in mouse models of sclerosing cholangitis, a disease so far lacking effective pharmacological therapy.

中文翻译：

---

单酰甘油脂肪酶抑制可防止硬化性胆管炎小鼠模型的肝损伤


单酰甘油脂肪酶 (MGL) 是甘油三酯降解的最后一个酶促步骤，将单甘油酯水解为甘油和脂肪酸 (FA)，并将 2-花生四烯酰甘油转化为花生四烯酸，从而为核受体提供配体，作为肝胆汁酸 (BA)/ 的关键调节剂脂质代谢和炎症。我们的目的是探讨 MGL 在硬化性胆管炎小鼠模型中胆汁淤积性肝和胆管损伤发展中的作用，硬化性胆管炎是一种迄今为止缺乏有效药物治疗的疾病。