Accumulated evidence shows that sperm-associated antigen 6 (SPAG6) gene has multiple biological functions. It maintains the normal function of a variety of cells including ciliary/flagellar biogenesis and polarization, neurogenesis, and neuronal migration. Moreover, SPAG6 is found to be critically involved in auditory transduction and the fibroblast life cycle. Furthermore, SPAG6 plays an essential role in immuno-regulation. Notably, SPAG6 has been demonstrated to participate in the occurrence and progression of a variety of human cancers. New evidence shows that SPAG6 gene regulates tumor cell proliferation, apoptosis, invasion, and metastasis. Therefore, in this review, we describe the physiological function and mechanism of SPAG6 in human normal cells and cancer cells. We also highlight that SPAG6 gene may be an effective biomarker for the diagnosis of human cancer. Taken together, targeting SPAG6 could be a novel strategy for the treatment of human diseases including cancer.

积累的证据表明，精子相关抗原6（SPAG6）基因具有多种生物学功能。它维持各种细胞的正常功能，包括睫状/鞭毛生物发生和极化，神经发生和神经元迁移。此外，发现SPAG6关键参与听觉传导和成纤维细胞的生命周期。此外，SPAG6在免疫调节中起着至关重要的作用。值得注意的是，SPAG6已被证明参与多种人类癌症的发生和发展。新证据表明，SPAG6基因调节肿瘤细胞的增殖，凋亡，侵袭和转移。因此，在这篇综述中，我们描述了SPAG6在人正常细胞和癌细胞中的生理功能和机制。我们还强调了SPAG6基因可能是诊断人类癌症的有效生物标志物。综上所述，靶向SPAG6可能是治疗包括癌症在内的人类疾病的新策略。