Trypanosomes have complex life cycles within which there are both proliferative and differentiation cell divisions. The coordination of the cell cycle to achieve these different divisions is critical for the parasite to infect both host and vector. From studying the regulation of the proliferative cell cycle of the Trypanosoma brucei procyclic life cycle stage, three subcycles emerge that control the duplication and segregation of (a) the nucleus, (b) the kinetoplast, and (c) a set of cytoskeletal structures. We discuss how the clear dependency relationships within these subcycles, and the potential for cross talk between them, are likely required for overall cell cycle coordination. Finally, we look at the implications this interdependence has for proliferative and differentiation divisions through the T. brucei life cycle and in related parasitic trypanosomatid species.

中文翻译：

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锥虫细胞周期的协调。

锥虫具有复杂的生命周期，在生命周期中既有增殖细胞也有分化细胞​​分裂。细胞周期的协调以实现这些不同的分裂对于寄生虫感染宿主和载体都是至关重要的。通过研究布鲁氏锥虫锥虫生命周期阶段增殖细胞周期的调控，出现了三个亚周期，它们控制着（a）核，（b）运动塑料和（c）一组细胞骨架结构的复制和分离。我们讨论了整个细胞周期协调可能如何需要这些子周期内明确的依赖关系以及它们之间潜在的串扰。最后，我们研究了这种相互依赖性对T分化和分化的影响。