The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of bacteria and controls many key functions and mechanisms. In the case of bacterial pathogens, a wide variety of virulence lifestyle factors have been shown to be regulated by c-di-GMP. Evidence of the importance of this molecule for bacterial pathogenesis has become so great that new antimicrobial agents are tested for their capacity of targeting c-di-GMP signaling. This review summarizes the current knowledge on this topic and reveals its application for the development of new antivirulence intervention strategies.

中文翻译：

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c-di-GMP信号在细菌发病中的多重作用。

细胞内信号分子环状双GMP（c-di-GMP）调节细菌的生活方式，并控制许多关键功能和机制。就细菌病原体而言，多种毒力生活方式因素已显示受c-di-GMP调节。该分子对于细菌发病机理的重要性的证据已经变得如此之多，以至于测试了新的抗菌剂靶向c-di-GMP信号传导的能力。这篇综述总结了有关该主题的当前知识，并揭示了其在开发新的抗病毒干预策略中的应用。