The Apicomplexa phylum includes a large group of obligate intracellular protozoan parasites responsible for important diseases in humans and animals. Toxoplasma gondii is a widespread parasite with considerable versatility, and it is capable of infecting virtually any warm-blooded animal, including humans. This outstanding success can be attributed at least in part to an efficient and continuous sensing of the environment, with a ready-to-adapt strategy. This review updates the current understanding of the signals governing the lytic cycle of T. gondii, with particular focus on egress from infected cells, a key step for balancing survival, multiplication, and spreading in the host. We cover the recent advances in the conceptual framework of regulation of microneme exocytosis that ensures egress, motility, and invasion. Particular emphasis is given to the trigger molecules and signaling cascades regulating exit from host cells.

中文翻译：

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弓形虫控制宿主细胞进入和离开宿主细胞的信号级联。

蚜虫门包括大量专性细胞内原生动物寄生虫，这些寄生虫负责人和动物的重要疾病。弓形虫是一种广泛传播的寄生虫，具有广泛的多功能性，并且能够感染几乎任何温血动物，包括人类。这种出色的成功至少可以部分归因于采用随时可用的策略对环境进行的有效且持续的感知。这篇综述更新了目前对控制弓形虫溶菌周期的信号的理解，特别是关注被感染细胞的流出，这是平衡宿主存活，繁殖和传播的关键步骤。我们介绍了微neo胞吐作用的调控概念框架中的最新进展，该构架可确保出口，运动和侵袭。