A Case study on the utility of predictive toxicology tools in alternatives assessments for hazardous chemicals in children's consumer products.,Journal of Exposure Science and Environmental Epidemiology

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A Case study on the utility of predictive toxicology tools in alternatives assessments for hazardous chemicals in children's consumer products.
Journal of Exposure Science and Environmental Epidemiology ( IF 4.1 ) Pub Date : 2019-09-09 , DOI: 10.1038/s41370-019-0165-y
Marissa N Smith ₁ , Elaine A Cohen Hubal ₂ , Elaine M Faustman ₁

Affiliation

Children's consumer products represent an important exposure source for many toxicants. Chemicals of high concern, as designated by the Washington State Child Safe Product Act include phthalates, Bisphenol A (BPA) and parabens, among others. As regulation and reporting requirements increase, so has demand for safer alternatives. This project examines how predictive toxicology and exposure comparison tools can fill gaps in alternatives assessments for hazardous chemicals found in children's products. Phthalates, parabens, BPA and their alternatives were assessed for endocrine disruption and reproductive toxicity using authoritative lists and US Environmental Protection Agency's (EPA) predictive toxicology and exposure comparison tools. Resources included the European Chemical Agency's Endocrine Disruptor Substances of Concern database, Global Harmonization System and Classification of Labeling Chemicals, Quantitative Structural Activity Relationships from the Toxicity Estimation Software Tool, the Toxicological Prioritization Index (ToxPi) score calculated from the ToxCast Database, and No Observable Adverse Effects Levels (NOAELs)/Highest No Effects Levels (HNEL) from animal studies found in the CompTox Chemistry Dashboard. Exposure was assessed using ExpoCast predictions. Though alternatives were rarely included in authoritative lists, predictive toxicology tools suggested that BPA alternatives may not be safer but paraben and phthalate alternatives may be safer. All four paraben and no bisphenol or phthalate alternatives were listed on EPA's Safer Chemical Ingredients List. Overall, we found that predictive toxicology tools help fill gaps for alternatives assessments when existing classifications are incomplete.

中文翻译：

关于预测毒理学工具在儿童消费品中危险化学品替代品评估中的效用的案例研究。

儿童消费品是许多有毒物质的重要接触源。华盛顿州儿童安全产品法指定的高度关注化学品包括邻苯二甲酸盐、双酚 A (BPA) 和对羟基苯甲酸酯等。随着监管和报告要求的增加，对更安全替代品的需求也在增加。该项目研究预测毒理学和暴露比较工具如何填补儿童产品中危险化学品替代品评估的空白。使用权威清单和美国环境保护署 (EPA) 的预测毒理学和暴露比较工具评估邻苯二甲酸盐、对羟基苯甲酸酯、BPA 及其替代品的内分泌干扰和生殖毒性。资源包括欧洲化学品管理局的内分泌干扰物质关注数据库、全球统一系统和标签化学品分类、毒性估计软件工具中的定量结构活性关系、根据 ToxCast 数据库计算的毒理学优先级指数 (ToxPi) 分数以及无观察值CompTox 化学仪表板中的动物研究得出的不良影响水平 (NOAEL)/最高无影响水平 (HNEL)。使用 ExpoCast 预测评估暴露情况。尽管替代品很少被列入权威列表，但预测毒理学工具表明，BPA 替代品可能并不更安全，但对羟基苯甲酸酯和邻苯二甲酸盐替代品可能更安全。所有四种对羟基苯甲酸酯且无双酚或邻苯二甲酸酯替代品均列在 EPA 的更安全化学成分列表中。总体而言，我们发现，当现有分类不完整时，预测毒理学工具有助于填补替代品评估的空白。

更新日期：2019-09-09

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