Biomaterials for Personalized Cell Therapy.,Advanced Materials

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Biomaterials for Personalized Cell Therapy.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-09-09 , DOI: 10.1002/adma.201902005
Amanda L Facklam _{1,

2} , Lisa R Volpatti _{1,

3} , Daniel G Anderson _{1,

3,

4,

5}

Affiliation

Cell therapy has already had an important impact on healthcare and provided new treatments for previously intractable diseases. Notable examples include mesenchymal stem cells for tissue regeneration, islet transplantation for diabetes treatment, and T cell delivery for cancer immunotherapy. Biomaterials have the potential to extend the therapeutic impact of cell therapies by serving as carriers that provide 3D organization and support cell viability and function. With the growing emphasis on personalized medicine, cell therapies hold great potential for their ability to sense and respond to the biology of an individual patient. These therapies can be further personalized through the use of patient-specific cells or with precision biomaterials to guide cellular activity in response to the needs of each patient. Here, the role of biomaterials for applications in tissue regeneration, therapeutic protein delivery, and cancer immunotherapy is reviewed, with a focus on progress in engineering material properties and functionalities for personalized cell therapies.

中文翻译：

个性化细胞疗法的生物材料。

细胞疗法已经对医疗保健产生了重要影响，并为以前的顽固性疾病提供了新的治疗方法。值得注意的例子包括用于组织再生的间充质干细胞，用于糖尿病治疗的胰岛移植以及用于癌症免疫疗法的T细胞递送。生物材料通过充当提供3D组织并支持细胞活力和功能的载体，具有扩展细胞疗法的治疗效果的潜力。随着对个性化医学的日益重视，细胞疗法因其感知和响应单个患者生物学的能力而具有巨大潜力。这些疗法可以通过使用患者特异性细胞或使用精确的生物材料来进一步个性化，以响应每个患者的需求来指导细胞活性。这里，

更新日期：2020-04-01

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