The absorption, distribution and excretion of drugs are largely determined by their transporters (DTs), the variability of which has thus attracted considerable attention. There are three aspects of variability: epigenetic regulation and genetic polymorphism, species/tissue/disease-specific DT abundances, and exogenous factors modulating DT activity. The variability data of each aspect are essential for clinical study, and a collective consideration among multiple aspects becomes crucial in precision medicine. However, no database is constructed to provide the comprehensive data of all aspects of DT variability. Herein, the Variability of Drug Transporter Database (VARIDT) was introduced to provide such data. First, 177 and 146 DTs were confirmed, for the first time, by the transporting drugs approved and in clinical/preclinical, respectively. Second, for the confirmed DTs, VARIDT comprehensively collected all aspects of their variability (23 947 DNA methylations, 7317 noncoding RNA/histone regulations, 1278 genetic polymorphisms, differential abundance profiles of 257 DTs in 21 781 patients/healthy individuals, expression of 245 DTs in 67 tissues of human/model organism, 1225 exogenous factors altering the activity of 148 DTs), which allowed mutual connection between any aspects. Due to huge amount of accumulated data, VARIDT made it possible to generalize characteristics to reveal disease etiology and optimize clinical treatment, and is freely accessible at: https://db.idrblab.org/varidt/ and http://varidt.idrblab.net/.

中文翻译：

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VARIDT 1.0：药物转运数据库的可变性。

药物的吸收，分布和排泄在很大程度上取决于其转运蛋白（DTs），因此其可变性引起了人们的极大关注。可变性包括三个方面：表观遗传调控和遗传多态性，物种/组织/疾病特异性DT丰度以及调节DT活性的外源因素。每个方面的变异性数据对于临床研究都是必不可少的，并且在精密医学中，多个方面之间的集体考虑变得至关重要。但是，没有构建数据库来提供DT变异性所有方面的全面数据。在此，引入了药物转运蛋白数据库的变异性（VARIDT）以提供此类数据。首先，首次通过批准的运输药物和在临床/临床前分别确认了177和146 DTs。其次，对于已确诊的DT，VARIDT全面收集了其变异性的所有方面（23 947个DNA甲基化，7317个非编码RNA /组蛋白法规，1278个遗传多态性，21 781名患者/健康个体中257个DT的差异丰度图，245个DT的表达在人类/模型生物的67个组织中，有1225个外源因子改变了148个DTs的活性），这使得各个方面之间可以相互联系。由于大量的累积数据，VARIDT使得概括特征以揭示疾病病因和优化临床治疗成为可能，并且可以从以下网址免费访问：https://db.idrblab.org/varidt/和http：//varidt.idrblab 。网/。1278个基因多态性，21 781名患者/健康个体中257个DT的差异丰度图谱，人类/模型生物的67个组织中245个DT的表达，改变148个DTs活性的1225个外源因子），这使得各个方面之间可以相互联系。由于大量的累积数据，VARIDT使得概括特征以揭示疾病病因和优化临床治疗成为可能，并且可以从以下网址免费访问：https：//db.idrblab.org/varidt/和http：//varidt.idrblab 。网/。1278个基因多态性，21 781名患者/健康个体中257个DT的差异丰度图谱，人类/模型生物的67个组织中245个DT的表达，改变148个DTs活性的1225个外源因子），这使得各个方面之间可以相互联系。由于大量的累积数据，VARIDT使得概括特征以揭示疾病病因和优化临床治疗成为可能，并且可以从以下网址免费访问：https://db.idrblab.org/varidt/和http：//varidt.idrblab 。网/。