当前位置: X-MOL 学术Traffic › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Germ granules in Drosophila.
Traffic ( IF 3.6 ) Pub Date : 2019-07-31 , DOI: 10.1111/tra.12674
Tatjana Trcek 1 , Ruth Lehmann 1
Affiliation  

Germ granules are hallmarks of all germ cells. Early ultrastructural studies in Drosophila first described these membraneless granules in the oocyte and early embryo as filled with amorphous to fibrillar material mixed with RNA. Genetic studies identified key protein components and specific mRNAs that regulate germ cell-specific functions. More recently these ultrastructural studies have been complemented by biophysical analysis describing germ granules as phase-transitioned condensates. In this review, we provide an overview that connects the composition of germ granules with their function in controlling germ cell specification, formation and migration, and illuminate these mysterious condensates as the gatekeepers of the next generation.

中文翻译:

果蝇中的毒菌颗粒。

胚芽颗粒是所有生殖细胞的标志。果蝇的早期超微结构研究首先描述了卵母细胞和早期胚胎中的这些无膜颗粒充满了混合有RNA的无定形至纤维状物质。遗传研究确定了调节生殖细胞特定功能的关键蛋白质成分和特定mRNA。最近,这些超微结构研究得到了生物物理分析的补充,这些生物物理分析将胚芽颗粒描述为相变冷凝物。在这篇综述中,我们提供了一个概述,将胚芽颗粒的组成与其在控制生殖细胞规格,形成和迁移中的功能联系在一起,并阐明了这些神秘的冷凝物,它们是下一代的守护者。
更新日期:2019-07-31
down
wechat
bug