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Genetic resilience to Alzheimer's disease in APOE ε4 homozygotes: A systematic review
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2019-09-07 , DOI: 10.1016/j.jalz.2019.05.011
Aamira J Huq 1 , Peter Fransquet 2 , Simon M Laws 3 , Joanne Ryan 2 , Robert Sebra 4 , Colin L Masters 5 , Ingrid M Winship 6 , Paul A James 6 , Paul Lacaze 2
Affiliation  

Individuals with homozygosity for the apolipoprotein E (APOE) ε4 allele are in the highest risk category for late‐onset Alzheimer's disease (LOAD). However, some individuals in this category do not develop LOAD beyond the age of 75 years, despite being at elevated genetic risk. These “resilient” individuals may carry protective genetic factors.

中文翻译:

APOE ε4 纯合子对阿尔茨海默病的遗传恢复力:系统评价

载脂蛋白 E (APOE) ε4 等位基因纯合子的个体属于晚发性阿尔茨海默病 (LOAD) 的最高风险类别。然而,尽管存在较高的遗传风险,但该类别中的一些人在 75 岁以后不会发展为 LOAD。这些“弹性”个体可能携带保护性遗传因素。
更新日期:2019-09-07
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