In vivo measures of tau burden are associated with atrophy in early Braak stage medial temporal lobe regions in amyloid-negative individuals,Alzheimer's & Dementia

当前位置： X-MOL 学术 › Alzheimers Dement. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

In vivo measures of tau burden are associated with atrophy in early Braak stage medial temporal lobe regions in amyloid-negative individuals
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2019-09-06 , DOI: 10.1016/j.jalz.2019.05.009
Sandhitsu R Das ₁ , Long Xie ₂ , Laura E M Wisse ₃ , Nicolas Vergnet ₄ , Ranjit Ittyerah ₂ , Salena Cui ₅ , Paul A Yushkevich ₆ , David A Wolk ₇ ,

Affiliation

Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA; Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA; Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA; Penn Alzheimer's Disease Core Center, University of Pennsylvania, Philadelphia, PA, USA.
Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA; Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA.
Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA.
Jefferson University, Philadelphia, PA, USA.
Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA, USA; Penn Alzheimer's Disease Core Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA; Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA; Penn Alzheimer's Disease Core Center, University of Pennsylvania, Philadelphia, PA, USA.

It is unclear the degree to which tau pathology in the medial temporal lobe (MTL) measured by 18F‐flortaucipir positron emission tomography relates to MTL subregional atrophy and whether this relationship differs between amyloid‐β–positive and amyloid‐β–negative individuals.

中文翻译：

tau 负荷的体内测量与淀粉样蛋白阴性个体早期 Braak 期内侧颞叶区域的萎缩有关

目前尚不清楚通过 18F-flortaucipir 正电子发射断层扫描测量的内侧颞叶 (MTL) 中的 tau 病理与 MTL 亚区域萎缩的相关程度，以及这种关系在淀粉样蛋白-β 阳性和淀粉样蛋白-β 阴性个体之间是否不同。

更新日期：2019-09-06

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文