Thiadiazole moieties are present in many natural products and pharmaceutical compounds that possess a broad spectrum of biological activities, serving as antidepressant, anxiolytic, antimicrobial, antitubercular, antiinflammatory, antidiabetic, anticancer, antihypertensive, or antifungal drugs. Many excellent methods have been reported for accessing such frameworks. In this review, we summarize advances made within the past ten years in the synthesis of various types of thiadiazole. 1 Introduction 2 Synthesis of Thiadiazoles 2.1 Synthesis of 1,2,3-Thiadiazoles 2.1.1 Synthesis of 1,2,3-Thiadiazoles from Diazo/Azide Compounds 2.1.2 Synthesis of 1,2,3-Thiadiazoles from Sulfonyl Hydrazines or N-Tosylhydrazones 2.2 Synthesis of 1,2,4-Thiadiazoles 2.2.1 Synthesis of 1,2,4-Thiadiazoles from Thioamides or their Derivatives 2.2.2 Synthesis of 1,2,4-Thiadiazoles from Amidines or 2-Aminopyridines 2.3 Synthesis of 1,3,4-Thiadiazoles 2.4 Synthesis of 1,2,5-Thiadiazoles 3 Conclusion

中文翻译：

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噻二唑类化合物的合成新进展

噻二唑部分存在于许多具有广谱生物活性的天然产物和药物化合物中，用作抗抑郁药、抗焦虑药、抗微生物药、抗结核药、抗炎药、抗糖尿病药、抗癌药、抗高血压药或抗真菌药。已经报道了许多用于访问此类框架的优秀方法。在这篇综述中，我们总结了过去十年在合成各种噻二唑方面取得的进展。1 引言 2 噻二唑的合成 2.1 1,2,3-噻二唑的合成 2.1.1 由重氮/叠氮化合物合成 1,2,3-噻二唑 2.1.2 由磺酰肼或 N 合成 1,2,3-噻二唑-甲苯磺酰腙 2.2 1,2,4-噻二唑的合成 2.2.1 从硫代酰胺或其衍生物合成 1,2,4-噻二唑 2.2.2 1,2 的合成，