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Profiles of maternal origin factors during transition from embryonic diapause to implantation in roe deer.
Animal Science Journal ( IF 1.7 ) Pub Date : 2019-09-04 , DOI: 10.1111/asj.13289
Anna J Korzekwa 1 , Angelika M Kotlarczyk 1 , Anna Zadroga 1
Affiliation  

The aim was to evaluate in female roe deer: (a) PAG mRNA relative abundance in endometrial uterine tissue for determination of the duration of embryonic diapause, (b) mRNA relative abundance of progesterone, estradiol, and prolactin (P4, E2, and PRL) receptors (PGR, ESR, and PRLR) during diapause and after implantation in the endometrium; (c) concentration of P4, E2, and PRL in the blood, and (d) a noninvasive method of hormone detection by measurement of P4 and E2 concentrations in feces. A total of fifteen individuals were obtained post mortem during hunting seasons and divided into three experimental groups (November, December, January). The results did not reveal mRNA relative abundance for PAGs in the endometrium or detectable PAG concentrations in the serum of all examined females. Concentration of PRL and mRNA relative abundance for PRLR long isoform in the endometrium was the highest in January (p < .01). mRNA relative abundance for PGR, P4 concentration in the endometrium, serum, and feces was the highest in January (p < .01). Endometrial origin PRL and P4 may be responsible for the termination of this process and pregnancy development after implantation.

中文翻译:

从胚胎滞育到implant的过渡期间母源因素的概况。

目的是评估雌性::(a)子宫内膜子宫组织中PAG mRNA相对丰度,以确定胚胎滞育的持续时间,(b)孕酮,雌二醇和催乳激素的mRNA相对丰度(P4,E2和PRL )滞育期间和子宫内膜植入后的受体(PGR,ESR和PRL​​R);(c)血液中P4,E2和PRL的浓度,以及(d)通过测量粪便中P4和E2浓度的非侵入性激素检测方法。在狩猎季节的尸检中总共获得了15个人,并将其分为三个实验组(11月,12月,1月)。结果未显示所有受检雌性子宫内膜中PAG的mRNA相对丰度或血清中可检测到的PAG浓度。一月份子宫内膜PRLR长同工型的PRL和mRNA相对丰度最高(p <.01)。1月,子宫内膜,血清和粪便中PGR,P4浓度的mRNA相对丰度最高(p <.01)。子宫内膜起源PRL和P4可能导致该过程的终止以及植入后的妊娠发展。
更新日期:2019-09-04
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