Perirhinal circuits for memory processing.,Nature Reviews Neuroscience

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Perirhinal circuits for memory processing.
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2019-09-04 , DOI: 10.1038/s41583-019-0213-6
Yasushi Miyashita ₁

Affiliation

The perirhinal cortex (PRC) serves as the gateway to the hippocampus for episodic memory formation and plays a part in retrieval through its backward connectivity to various neocortical areas. First, I present the evidence suggesting that PRC neurons encode both experientially acquired object features and their associative relations. Recent studies have revealed circuit mechanisms in the PRC for the retrieval of cue-associated information, and have demonstrated that, in monkeys, PRC neuron-encoded information can be behaviourally read out. These studies, among others, support the theory that the PRC converts visual representations of an object into those of its associated features and initiates backward-propagating, interareal signalling for retrieval of nested associations of object features that, combined, extensionally represent the object meaning. I propose that the PRC works as the ventromedial hub of a 'two-hub model' at an apex of the hierarchy of a distributed memory network and integrates signals encoded in other downstream cortical areas that support diverse aspects of knowledge about an object.

中文翻译：

用于记忆处理的 Perirhinal 电路。

鼻周皮层 (PRC) 作为海马体形成情景记忆的门户，并通过其与各个新皮层区域的反向连接在检索中发挥作用。首先，我提出证据表明PRC神经元编码经验获得的对象特征及其关联关系。最近的研究揭示了 PRC 中用于检索提示相关信息的电路机制，并表明，在猴子中，PRC 神经元编码的信息可以在行为上被读出。这些研究，除其他外，支持这样的理论，即PRC将对象的视觉表示转换为其相关特征的表示，并启动反向传播、区域间信号以检索对象特征的嵌套关联，这些关联结合，外延地表示对象的意义。我建议PRC在分布式记忆网络层次结构的顶点作为“双中心模型”的腹内侧中心工作，并整合在其他下游皮层区域编码的信号，这些区域支持关于对象的知识的不同方面。

更新日期：2019-09-05

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