Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring,Trends in Endocrinology & Metabolism

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Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2019-10-01 , DOI: 10.1016/j.tem.2019.07.021
Marta Calatayud ₁ , Omry Koren ₂ , Maria Carmen Collado ₃

Affiliation

Maternal nutritional, metabolic, and physiological states, as well as exposure to various environmental factors during conception, gestation, and lactation, have a fundamental role in the health programming of the offspring. Therefore, alterations affecting the maternal microbiota might indirectly influence fetal development. In addition, such alterations could be transmitted to the progeny at different stages of infant development (e.g., preconception, prenatal, or postnatal), thereby favoring the development of an altered microbiota in the neonate. Microbial changes of this kind have been linked to an increased risk of non-communicable diseases (NCDs), including obesity and metabolic syndrome, allergy-related problems, and diabetes. In this review, we summarize the relevance of the maternal microbiota to fetal-neonatal health programming, with a focus on maternal nutritional and metabolic states.

中文翻译：

母体微生物组和代谢健康计划微生物组发育和后代健康

母体的营养、代谢和生理状态，以及在受孕、妊娠和哺乳期间暴露于各种环境因素，对后代的健康规划具有重要作用。因此，影响母体微生物群的改变可能会间接影响胎儿的发育。此外，这种改变可以在婴儿发育的不同阶段（例如，孕前、产前或产后）传递给后代，从而有利于新生儿微生物群的发育。这种微生物变化与非传染性疾病 (NCD) 的风险增加有关，包括肥胖和代谢综合征、过敏相关问题和糖尿病。在这篇综述中，我们总结了母体微生物群与胎儿 - 新生儿健康规划的相关性，

更新日期：2019-10-01

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