Logical design of oral glucose ingestion pattern minimizing blood glucose in humans.,npj Systems Biology and Applications

当前位置： X-MOL 学术 › npj Syst. Biol. Appl. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Logical design of oral glucose ingestion pattern minimizing blood glucose in humans.
npj Systems Biology and Applications ( IF 3.5 ) Pub Date : 2019-09-02 , DOI: 10.1038/s41540-019-0108-1
Masashi Fujii _{1,

2,

3} , Yohei Murakami ₄ , Yasuaki Karasawa _{5,

6} , Yohei Sumitomo ₂ , Suguru Fujita ₂ , Masanori Koyama ₇ , Shinsuke Uda ₈ , Hiroyuki Kubota ₈ , Hiroshi Inoue ₉ , Katsumi Konishi ₁₀ , Shigeyuki Oba ₄ , Shin Ishii _{4,

11} , Shinya Kuroda _{1,

2,

11}

Affiliation

1Molecular Genetic Research Laboratory, Graduate School of Science, The University of Tokyo, Tokyo, 113-0033 Japan.
2Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, 113-0033 Japan.
11Present Address: Department of Integrated Sciences for Life, Graduate School of Integrated Sciences for Life, Hiroshima University, Hiroshima, 739-8526 Japan.
3Department of Systems Science, Graduate School of Informatics, Kyoto University, Kyoto, 606-8501 Japan.
Department of Neurosurgery, The University of Tokyo Hospital, The University of Tokyo, Tokyo, 113-0033 Japan.
5Department of Rehabilitation, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan.
6Department of Mathematics, Graduate School of Science and Engineering, Ritsumeikan University, Shiga, 525-8577 Japan.
7Division of Integrated Omics, Research Center for Transomics Medicine, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 812-8582 Japan.
8Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative, Kanazawa University, Ishikawa, 920-8640 Japan.
9Faculty of Computer and Information Sciences, Hosei University, Tokyo, 184-8584 Japan.
10CREST, Japan Science and Technology Agency, Tokyo, 113-0033 Japan.

Excessive increase in blood glucose level after eating increases the risk of macroangiopathy, and a method for not increasing the postprandial blood glucose level is desired. However, a logical design method of the dietary ingestion pattern controlling the postprandial blood glucose level has not yet been established. We constructed a mathematical model of blood glucose control by oral glucose ingestion in three healthy human subjects, and predicted that intermittent ingestion 30 min apart was the optimal glucose ingestion patterns that minimized the peak value of blood glucose level. We confirmed with subjects that this intermittent pattern consistently decreased the peak value of blood glucose level. We also predicted insulin minimization pattern, and found that the intermittent ingestion 30 min apart was optimal, which is similar to that of glucose minimization pattern. Taken together, these results suggest that the glucose minimization is achieved by suppressing the peak value of insulin concentration, rather than by enhancing insulin concentration. This approach could be applied to design optimal dietary ingestion patterns.

中文翻译：

口服葡萄糖摄入模式的逻辑设计可最大限度地减少人类血糖。

进食后血糖水平过度升高会增加大血管病的风险，因此需要一种不升高餐后血糖水平的方法。然而，控制餐后血糖水平的膳食摄入模式的逻辑设计方法尚未建立。我们在三名健康受试者中构建了通过口服葡萄糖摄入控制血糖的数学模型，并预测间隔 30 分钟的间歇摄入是最佳的葡萄糖摄入模式，可以最大限度地降低血糖水平的峰值。我们向受试者证实，这种间歇模式持续降低血糖水平的峰值。我们还预测了胰岛素最小化模式，发现间隔30分钟的间歇摄入是最佳的，这与葡萄糖最小化模式类似。总而言之，这些结果表明葡萄糖最小化是通过抑制胰岛素浓度的峰值来实现的，而不是通过提高胰岛素浓度来实现的。这种方法可用于设计最佳饮食摄入模式。

更新日期：2019-09-02

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文