Although premature ejaculation (PE) is a common male sexual dysfunction, its pathophysiology has not been fully elucidated. Several medical problems such as erectile dysfunction, depression, anxiety, hormonal disorders and chronic prostatitis may play a role in the etiology of acquired PE. This study aims to evaluate the frequency of these etiologic factors among patients with acquired PE. Between May and July 2016, 53 men with acquired PE were included in the study. Self-estimated intravaginal ejaculation latency time (IELT) of these patients was recorded along with their medical history and physical examination findings. Moreover, 5-item version of the International Index of Erectile Function (IIEF-5), premature ejaculation profile (PEP), anxiety and depression scales (STAI-1, STAI-2, and BECK), and chronic prostatitis symptom index (NIH-CPSI) were administered. Fasting plasma glucose, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, total and free testosterone, total prostate specific antigen, thyroid and thyroid stimulating hormone levels were measured. Urine analysis and 2 cup tests were also studied. Mean age of the patients was 42.41 ± 11.14 (22-60). Mean duration of the PE complaint was 34.18 ± 36.76 (3-144) months. Mean IELT time of the patients was 38.28 ± 30.79 (3-180) s. Of the patients; 69.81%, 62.26%, 56.60%, 45.28%, 30.19%, 24.53%, 16.98%, 15.09%, and 7.55% had depression, chronic prostatitis, erectile dysfunction, anxiety, diabetes mellitus, abnormal FSH or LH, hypoprolactinemia, hyperthyroidism, and high testosterone levels, respectively. The results of our study revealed that anxiety disorders, depression, erectile dysfunction, and chronic prostatitis are common among patients with acquired PE and may play role in the etiology of this problem. There is a need for further researches related to the exact pathophysiology of acquired PE with larger number of patients.

中文翻译：

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获得性早泄患者的病因因素频率：前瞻性，观察性，单中心研究。

尽管早泄（PE）是男性常见的性功能障碍，但其病理生理学尚未完全阐明。诸如勃起功能障碍，抑郁，焦虑，荷尔蒙失调和慢性前列腺炎等几种医学问题可能在获得性PE的病因中起作用。本研究旨在评估获得性PE患者中这些病因的发生频率。在2016年5月至2016年7月之间，该研究纳入了53名获得性PE的男性。记录这些患者的自我估计的阴道内射精潜伏时间（IELT）以及他们的病史和体格检查结果。此外，国际勃起功能指数（IIEF-5），早泄概况（PEP），焦虑和抑郁量表（STAI-1，STAI-2和BECK）的5个项目，和慢性前列腺炎症状指数（NIH-CPSI）进行了管理。测定了空腹血糖，卵泡刺激素（FSH），黄体生成素（LH），催乳素，总和游离睾丸激素，总前列腺特异性抗原，甲状腺和甲状腺刺激激素水平。尿液分析和2杯测试也进行了研究。患者的平均年龄为42.41±11.14（22-60）。PE投诉的平均持续时间为34.18±36.76（3-144）个月。患者的平均IELT时间为38.28±30.79（3-180）s。在患者中；69.81％，62.26％，56.60％，45.28％，30.19％，24.53％，16.98％，15.09％和7.55％患有抑郁症，慢性前列腺炎，勃起功能障碍，焦虑症，糖尿病，FSH或LH异常，泌乳素不足症，甲状腺功能亢进症，和高睾丸激素水平。我们的研究结果表明，焦虑症，抑郁症，勃起功能障碍和慢性前列腺炎在获得性PE患者中很常见，并且可能在此问题的病因中起作用。需要与更多患者获得性PE的确切病理生理相关的进一步研究。