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Efficacy of a preprostatectomy multi-modal penile rehabilitation regimen on recovery of postoperative erectile function.
International Journal of Impotence Research ( IF 2.8 ) Pub Date : 2019-09-02 , DOI: 10.1038/s41443-019-0187-y
Vadim Osadchiy 1 , Sriram V Eleswarapu 1 , Steven A Mills 1 , Matthew E Pollard 1 , Robert E Reiter 1 , Jesse N Mills 1
Affiliation  

To evaluate the efficacy of a novel, multi-modal, preoperative approach to postprostatectomy penile rehabilitation (PR), we performed a retrospective review of patients who underwent nerve-sparing robotic-assisted laparoscopic prostatectomy (NS-RALP). All patients were evaluated at a comprehensive, academic sexual medicine clinic between 2016 and 2017. The "prehabilitation" PR group (n = 106) consisted of men who were seen in the pre-op period and began tadalafil and L-citrulline 2 weeks prior to surgery. Vacuum erectile device (VED) therapy was started at 1-month post-op. These interventions were continued throughout the 12-month follow-up period. Individuals refractory to these therapies could start treatment with intracavernosal injections. The postprostatectomy PR group (n = 25) consisted of men who were not seen in the pre-op period and started the above therapies immediately following their first visit. A higher percentage of men in the prehabilitation group reported return of erectile function within 12 months (56% vs. 24%, P = 0.007). The prehabilitation group also showed better compliance with PR (PDE5i [96% vs. 64%, P < 0.001], L-citrulline [93% vs. 49%, P < 0.001], and VED [55% vs. 20%, P < 0.001]). Seventy-eight percent of men who attended 4-5 follow-up visits reported return of erectile function. Our results suggest that men undergoing a preoperative protocol show superior recovery of erectile function following NS-RALP. Further studies with prospective designs are warranted.

中文翻译:

前列腺切除术前多模式阴茎康复方案对术后勃起功能恢复的疗效。

为了评估新颖,多模式,术前方法对前列腺切除术后阴茎康复(PR)的疗效,我们对接受神经保护的机器人辅助腹腔镜前列腺切除术(NS-RALP)的患者进行了回顾性回顾。在2016年至2017年之间,所有患者均在一家综合性学术性医学诊所接受了评估。“康复” PR组(n = 106)由在手术前就诊的男性组成,他们在2周前开始使用他达拉非和L-瓜氨酸去手术。术后1个月开始使用真空勃起装置(VED)治疗。这些干预措施在整个12个月的随访期内一直持续进行。难于接受这些疗法的患者可以开始海绵体内注射治疗。前列腺切除术后PR组(n = 25)由在手术前未见过的男性组成,并在首次就诊后立即开始上述治疗。康复前组中较高比例的男性报告勃起功能在12个月内恢复(56%比24%,P = 0.007)。康复前组也表现出更好的PR依从性(PDE5i [96%vs. 64%,P <0.001],L-瓜氨酸[93%vs. 49%,P <0.001]和VED [55%vs. 20%, P <0.001])。参加4-5次随访的男性中有78%的人报告勃起功能恢复。我们的研究结果表明,接受术前检查的男性在NS-RALP术后勃起功能恢复良好。必须对前瞻性设计进行进一步研究。康复前组中较高比例的男性报告勃起功能在12个月内恢复(56%比24%,P = 0.007)。康复前组也表现出更好的PR依从性(PDE5i [96%vs. 64%,P <0.001],L-瓜氨酸[93%vs. 49%,P <0.001]和VED [55%vs. 20%, P <0.001])。参加4-5次随访的男性中有78%的人报告勃起功能恢复。我们的研究结果表明,接受术前检查的男性在NS-RALP术后勃起功能恢复良好。必须对前瞻性设计进行进一步研究。康复前组中较高比例的男性报告勃起功能在12个月内恢复(56%比24%,P = 0.007)。康复前组也表现出更好的PR依从性(PDE5i [96%vs. 64%,P <0.001],L-瓜氨酸[93%vs. 49%,P <0.001]和VED [55%vs. 20%, P <0.001])。参加4-5次随访的男性中有78%的人报告勃起功能恢复。我们的研究结果表明,接受术前检查的男性在NS-RALP术后勃起功能恢复良好。必须对前瞻性设计进行进一步研究。和VED [55%对20%,P <0.001])。参加4-5次随访的男性中有78%的人报告勃起功能恢复。我们的结果表明,接受术前检查的男性在NS-RALP术后勃起功能恢复良好。必须对前瞻性设计进行进一步研究。和VED [55%对20%,P <0.001])。参加4-5次随访的男性中有78%的人报告勃起功能恢复。我们的研究结果表明,接受术前检查的男性在NS-RALP术后勃起功能恢复良好。必须对前瞻性设计进行进一步研究。
更新日期:2019-09-03
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