Recently, focus has turned towards increasing chemical process safety and sustainability for fundamental and applied research as well as manufacturing of pharmaceuticals and specialty chemicals. Flow chemistry techniques have attracted significant interest as a way to implement and improve chemical processes in order to satisfy the growing demand for chemical sustainability. In this article, we discuss emerging flow chemistry technologies with applications in green manufacturing of high-value chemicals and efficient screening of chemical reaction space. Continuous manufacturing techniques are increasingly being utilized to reduce the amount of material and energy utilized in a process while incorporating real-time analysis, control, and enhanced process safety. Beyond continuous production, flow screening techniques can rapidly search a multi-dimensional reaction space to improve process design, performance, and efficiency. Furthermore, time-efficient and material-efficient (green) flow screening platforms can be utilized to develop the next generation of process development technologies including predictive reaction models and process scale-up strategies.

最近，重点已转向提高化学过程的安全性和可持续性，以用于基础和应用研究以及药品和特种化学品的生产。流动化学技术作为一种实施和改进化学过程的方法，已引起人们极大的兴趣，以满足对化学可持续性不断增长的需求。在本文中，我们将讨论新兴的流化学技术及其在绿色制造高价值化学品和有效筛选化学反应空间中的应用。在结合实时分析，控制和增强的过程安全性的同时，越来越多地采用连续制造技术来减少过程中使用的材料和能量。除了连续生产，流动筛分技术可以快速搜索多维反应空间，以改善工艺设计，性能和效率。此外，省时省力（绿色）流程筛选平台可用于开发下一代流程开发技术，包括预测性反应模型和流程放大策略。