The Biological Applications of Two Aggregation-Induced Emission Luminogens.,Biotechnology Journal

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The Biological Applications of Two Aggregation-Induced Emission Luminogens.
Biotechnology Journal ( IF 3.2 ) Pub Date : 2019-09-17 , DOI: 10.1002/biot.201900212
Meijia Gu _{1,

2} , Zixuan Zeng ₁ , Mai Xing ₁ , Yige Xiong ₁ , Zixin Deng ₁ , Shi Chen _{1,

2} , Lianrong Wang _{1,

2}

Affiliation

Fluorescence imaging, as a commonly used scientific tool, is widely applied in various biomedical and material structures through visualization technology. Highly selective and sensitive luminescent biological probes, as well as those with good water solubility, are urgently needed for biomedical research. In contrast to the traditional aggregation-caused quenching of fluorescence, in the unique phenomenon of aggregation-induced emission (AIE), the individual luminogens have extremely weak or no emissivity because they each have free intramolecular motion; however, when they form aggregates, these components immediately "light up". Since the discovery of "turn-on" mechanism, researchers have been studying and applying AIE in a variety of fields to develop more sensitive, selective, and efficient strategies for the AIE dyes. There are numerous advantages to the use of AIE-based methods, including low background interference, strong contrast, high performance in intracellular imaging, and the ability for long-term monitoring in vivo. In this review, two typical examples of AIEgens, TPE-Cy and TPE-Ph-In, are described, including their structure properties and applications. Recent progress in the biological applications is mainly focused on. Undoubtedly, in the near future, an increasing number of encouraging and practical ideas will promote the development of more AIEgens for broad use in biomedical applications.

中文翻译：

两种聚集诱导的发光源的生物学应用。

荧光成像作为一种常用的科学工具，通过可视化技术已广泛应用于各种生物医学和材料结构中。生物医学研究迫切需要高度选择性和灵敏的发光生物探针以及具有良好水溶性的探针。与传统的聚集引起的荧光猝灭相反，在聚集诱导发射（AIE）的独特现象中，单个发光剂具有极弱的或没有发射率，因为它们各自具有自由的分子内运动。但是，当它们形成聚集体时，这些组件会立即“点亮”。自从发现“开启”机制以来，研究人员一直在各种领域研究和应用AIE，以开发出更灵敏，选择性和有效的AIE染料策略。使用基于AIE的方法有许多优点，包括低背景干扰，强对比度，细胞内成像的高性能以及体内长期监测的能力。在这篇综述中，描述了AIEgens的两个典型实例，TPE-Cy和TPE-Ph-In，包括它们的结构性质和应用。生物学应用的最新进展主要集中在。毫无疑问，在不久的将来，越来越多的鼓舞人心和实用的想法将促进更多AIEgens的开发，以广泛应用于生物医学应用。描述了TPE-Cy和TPE-Ph-In，包括其结构性质和应用。生物学应用的最新进展主要集中在。毫无疑问，在不久的将来，越来越多的鼓舞人心和实用的想法将促进更多AIEgens的开发，以广泛应用于生物医学应用。描述了TPE-Cy和TPE-Ph-In，包括其结构性质和应用。生物学应用的最新进展主要集中在。毫无疑问，在不久的将来，越来越多的鼓舞人心和实用的想法将促进更多AIEgens的开发，以广泛应用于生物医学应用。

更新日期：2019-09-18

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