当前位置: X-MOL 学术J. Antibiot. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Mechanism of action of nucleoside antibacterial natural product antibiotics.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-08-30 , DOI: 10.1038/s41429-019-0227-3
Timothy D H Bugg 1 , Rachel V Kerr 1
Affiliation  

This article reviews the structures and biological activities of several classes of uridine-containing nucleoside antibiotics (tunicamycins, mureidomycins/pacidamycins/sansanmycins, liposidomycins/caprazamycins, muraymycins, capuramycins) that target translocase MraY on the peptidoglycan biosynthetic pathway. In particular, recent advances in structure-function studies, and recent X-ray crystal structures of translocase MraY complexed with muraymycin D2 and tunicamycin are described. The inhibition of other phospho-nucleotide transferase enzymes related to MraY by nucleoside antibiotics and analogues is also reviewed.

中文翻译:

核苷类抗菌天然产物抗生素的作用机制。

本文综述了几类以肽聚糖生物合成途径中的转位酶 MraY 为靶点的含尿苷核苷类抗生素(衣霉素、穆雷多霉素/帕西霉素/三三霉素、脂质霉素/卡普拉扎霉素、穆雷霉素、卡普拉霉素)的结构和生物活性。特别是结构-功能研究的最新进展,以及最近与穆雷霉素 D2 和衣霉素复合的易位酶 MraY 的 X 射线晶体结构。还综述了核苷类抗生素和类似物对其他与 MraY 相关的磷酸核苷酸转移酶的抑制作用。
更新日期:2020-01-17
down
wechat
bug