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Maternal Envelope gp41 Ectodomain-Specific Antibodies Are Associated With Increased Mother-to-Child Transmission of Human Immunodeficiency Virus-1.
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-01-02 , DOI: 10.1093/infdis/jiz444
Nicole E Naiman 1, 2, 3 , Jennifer Slyker 4, 5 , Ruth Nduati 6 , Julie M Overbaugh 1, 7
Affiliation  

Mother-to-child transmission of human immunodeficiency virus (HIV) occurs in the setting of maternal and passively acquired antibodies, providing a unique window into immune correlates of HIV risk. We compared plasma antibody binding to HIV antigens between 51 nontransmitting mother-infant pairs and 21 transmitting mother-infant pairs. Plasma antibody binding to a variety of gp41 ectodomain-containing antigens was associated with increased odds of transmission. Understanding the reasons why gp41 ectodomain-targeting antibodies are associated with transmission risk will be important in determining whether they can directly enhance infection or whether their presence reflects a redirecting of the humoral response away from targeting more protective epitopes.

中文翻译:

产妇信封gp41 Ectodomain特异性抗体与人类免疫缺陷病毒1的母婴传播增加有关。

人类免疫缺陷病毒(HIV)的母婴传播发生在母源抗体和被动获得性抗体的环境中,为了解HIV风险的免疫相关因素提供了独特的窗口。我们比较了51对非传播母婴对和21对传播母婴对之间与HIV抗原结合的血浆抗体。与多种含gp41胞外域的抗原结合的血浆抗体与传播几率增加有关。理解为什么靶向gp41胞外域的抗体与传播风险相关的原因对于确定它们是否可以直接增强感染或它们的存在是否反映了体液反应的重定向而不是靶向更具保护性的表位非常重要。
更新日期:2019-12-30
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