Photoactive Nanocarriers for Controlled Delivery,Advanced Functional Materials

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Photoactive Nanocarriers for Controlled Delivery
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2019-08-28 , DOI: 10.1002/adfm.201903896
Qirong Xiong ₁ , Yun Lim ₁ , Di Li ₂ , Kanyi Pu ₁ , Li Liang ₂ , Hongwei Duan ₁

Affiliation

Photoactive nanocarriers have emerged as robust and minimally invasive systems for the on‐demand delivery of active payloads. The easy manipulation offered by light irradiation as an external stimulus allows precise spatiotemporal control of payload release based on the time, intensity, location, and wavelength of light exposure. Compared to conventional passive delivery systems, photoactive nanocarriers offer the possibility of tailoring the release kinetics of the encapsulated active molecules, which is of considerable clinical relevance for targeted delivery to desired sites of interest. In this progress report, the recent advances in the design and fabrication of photoactive nanoplatforms based on three main modes of mechanisms: photochemical reactions, the photothermal effect, and photosensitization mechanism mediated by reactive oxygen species are highlighted. The combination of these mechanisms provides additional flexibility for the effective delivery of therapeutics and improved synergistic therapeutic effects. Finally, challenges in future perspectives on the development of photoactive nanomaterials and their medical translation are discussed.

中文翻译：

用于控制传递的光敏纳米载体

光活性纳米载体已成为按需递送活性有效载荷的强大且微创的系统。通过光照射作为外部刺激，操作简便，可根据曝光时间，强度，位置和波长精确控制时空释放。与常规的被动递送系统相比，光敏纳米载体提供了调整包封的活性分子的释放动力学的可能性，这对于靶向递送到所需的感兴趣部位具有相当大的临床意义。在此进展报告中，基于以下三种主要机理模式，在光活性纳米平台的设计和制造方面取得了最新进展：光化学反应，光热效应，突出了活性氧介导的光敏机理。这些机制的组合为有效递送治疗剂和改善的协同治疗效果提供了额外的灵活性。最后，讨论了光敏纳米材料的发展及其医学翻译在未来前景中的挑战。

更新日期：2020-01-11

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