Estimated 2017 tuberculosis (TB) incidence is 10 million and mainly depends on the reservoir of individuals with latent TB infection (LTBI). QuantiferonⓇ-TB Gold in-Tube (QFT-GIT) is one of the tests used for LTBI detection. Since 2015 a new version, QuantiferonⓇ-TB Gold Plus (QFT-Plus) is available. OBJECTIVES To perform a systematic review and meta-analysis to assess the diagnostic accuracy for TB of QFT-Plus compared to QFT-GIT. METHODS PubMed and Scopus were used to detect records related to predefined strings from 2015 to 2018. Full text articles dealing with the sensitivity and/or specificity of the QFT-Plus vs. QFT-GIT for active-TB and LTBI detection were analyzed. Scientific quality and risk of bias were assessed using QADAS-2. RESULTS We selected 15 articles. Studies were mainly observational and cross-sectional, performed in 8 countries. Sample size differed in the TB group (27 to 164) compared to LTBI group (29 to 1031). Pooled sensitivity of QFT-Plus for active-TB was 0.94 (0.91 and 0.95 for TB1 and TB2, respectively), whereas pooled specificity for healthy status was 0.96. Pooled sensitivity and specificity for LTBI was 0.91 and 0.95, respectively. CONCLUSIONS We show that QFT-Plus is more sensitive compared to QFT-GIT for detecting M. tuberculosis infection, mainly due to TB2 responses.

中文翻译：

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用于肺结核诊断的QuantiFERON TB Gold Plus：系统评价和荟萃分析。

据估计，2017年结核病（TB）发病率为1000万，主要取决于潜在潜伏性结核感染（LTBI）的患者库。Quantiferon-TB黄金管（QFT-GIT）是用于LTBI检测的测试之一。自2015年以来，已经推出了新版本Quantiferon®-TBGold Plus（QFT-Plus）。目的进行系统评价和荟萃分析，以评估QFT-Plus与QFT-GIT相比对TB的诊断准确性。方法使用PubMed和Scopus检测2015年至2018年与预定义字符串相关的记录。分析了有关QFT-Plus与QFT-GIT对活动性TB和LTBI检测的敏感性和/或特异性的全文。使用QADAS-2评估科学质量和偏见风险。结果我们选择了15篇文章。研究主要是观察性研究和横断面研究，在8个国家/地区演出。与LTBI组（29到1031）相比，TB组（27到164）的样本量有所不同。QFT-Plus对活动性结核病的合并敏感性为0.94（对TB1和TB2的合并敏感性分别为0.91和0.95），而对健康状态的合并特异性为0.96。LTBI的合并敏感性和特异性分别为0.91和0.95。结论我们显示，与QFT-GIT相比，QFT-Plus对于检测结核分枝杆菌感染更为敏感，这主要归因于TB2反应。