From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides.,Natural Product Reports

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From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides.
Natural Product Reports ( IF 10.2 ) Pub Date : 2020-02-26 , DOI: 10.1039/c9np00033j
Steffen Köcher ₁ , Sarah Resch ₁ , Till Kessenbrock ₁ , Lukas Schrapp ₁ , Michael Ehrmann ₂ , Markus Kaiser ₁

Affiliation

Covering: 1989 up to 2019 Ahp-cyclodepsipeptides (also known as Ahp-containing cyclodepsipeptides, cyanopeptolins, micropeptins, microginines, and lyngbyastatins, and by many other names) are a family of non-ribosomal peptide synthesis (NRPS)-derived natural products with potent serine protease inhibitory properties. Here, we review their isolation and structural elucidation from natural sources as well as studies of their biosynthesis, molecular mode of action, and use in drug discovery efforts. Accordingly, this summary aims to provide a comprehensive overview of the current state-of-the-art Ahp-cyclodepsipeptide research.

中文翻译：

从dolastatin 13到cyanepteptolins，micropeptins和lyngbyastatins：Ahp-cyclodepseptepteptides的化学生物学。

涵盖范围：1989年至2019年Ahp-环二肽（也称为含Ahp的环二肽，氰基肽，微肽，微甘氨酸和lyngbyastatins等）是非核糖体肽合成（NRPS）衍生的天然产物家族，具有强大的丝氨酸蛋白酶抑制特性。在这里，我们回顾了它们从天然来源的分离和结构解析，以及它们的生物合成，分子作用方式以及在药物开发中的用途的研究。因此，本概述旨在提供对当前最新的Ahp-环二肽肽研究的全面概述。

更新日期：2020-02-26

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