Cyclodipeptide synthases: a promising biotechnological tool for the synthesis of diverse 2,5-diketopiperazines.,Natural Product Reports

当前位置： X-MOL 学术 › Nat. Prod. Rep. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Cyclodipeptide synthases: a promising biotechnological tool for the synthesis of diverse 2,5-diketopiperazines.
Natural Product Reports ( IF 10.2 ) Pub Date : 2020-03-25 , DOI: 10.1039/c9np00036d
Nicolas Canu ₁ , Mireille Moutiez ₁ , Pascal Belin ₁ , Muriel Gondry ₁

Affiliation

Covering: Up to mid-2019 Cyclodipeptide synthases (CDPSs) catalyse the formation of cyclodipeptides using aminoacylated-tRNA as substrates. The recent characterization of large sets of CDPSs has revealed that they can produce highly diverse products, and therefore have great potential for use in the production of different 2,5-diketopiperazines (2,5-DKPs). Sequence similarity networks (SSNs) are presented as a new, efficient way of classifying CDPSs by specificity and identifying new CDPS likely to display novel specificities. Several strategies for further increasing the diversity accessible with these enzymes are discussed here, including the incorporation of non-canonical amino acids by CDPSs and use of the remarkable diversity of 2,5-DKP-tailoring enzymes discovered in recent years.

中文翻译：

环二肽合酶：一种有前途的生物技术工具，可用于合成各种2，5-二酮哌嗪。

涵盖范围：直到2019年中，环二肽合酶（CDPS）以氨基酰化的tRNA为底物催化环二肽的形成。大型CDPS的最新特征表明，它们可以生产高度多样化的产品，因此在生产不同的2,5-二酮哌嗪（2,5-DKPs）方面具有巨大的潜力。序列相似性网络（SSN）是一种通过特异性对CDPS进行分类并识别可能显示新颖特异性的新CDPS的有效新方法。本文讨论了进一步提高这些酶可及性的几种策略，包括CDPS结合非典型氨基酸，以及使用近年来发现的2,5-DKP定制酶的显着多样性。

更新日期：2020-03-26

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11