BACKGROUND Resting-state functional neuroimaging captures large-scale network organization; whether this organization is intact or disrupted during adolescent development across the psychosis spectrum is unresolved. We investigated the integrity of network organization in psychosis spectrum youth and those with first episode psychosis (FEP) from late childhood through adulthood. METHODS We analyzed data from Philadelphia Neurodevelopmental Cohort (PNC; typically developing = 450, psychosis spectrum = 273, 8-22 years), a longitudinal cohort of typically developing youth (LUNA; N = 208, 1-3 visits, 10-25 years), and a sample of FEP (N = 39) and matched controls (N = 34). We extracted individual time series and calculated correlations from brain regions and averaged them for 4 age groups: late childhood, early adolescence, late adolescence, adulthood. Using multiple analytic approaches, we assessed network stability across 4 age groups, compared stability between controls and psychosis spectrum youth, and compared group-level network organization of FEP to controls. We explored whether variability in cognition or clinical symptomatology was related to network organization. RESULTS Network organization was stable across the 4 age groups in the PNC and LUNA typically developing youth and PNC psychosis spectrum youth. Psychosis spectrum and typically developing youth had similar functional network organization during all age ranges. Network organization was intact in PNC youth who met full criteria for psychosis and in FEP. Variability in cognitive functioning or clinical symptomatology was not related to network organization in psychosis spectrum youth or FEP. DISCUSSION These findings provide rigorous evidence supporting intact functional network organization in psychosis risk and psychosis from late childhood through adulthood.

中文翻译：

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静息状态功能网络组织对于典型和精神病频谱青年来说在整个青少年发育过程中都是稳定的。

背景技术静止状态功能性神经成像捕获了大规模的网络组织。这个组织是完整的还是在整个精神病学时期的青少年发展过程中受到破坏，都尚未得到解决。我们调查了从儿童晚期到成年期的精神病谱青年和首发精神病（FEP）的网络组织的完整性。方法我们分析了来自费城神经发育队列（PNC；典型正在发展= 450，精神病谱= 273，8-22岁）的数据，该队列是典型发育中的青年的纵向队列（LUNA； N = 208，1-3次探访，10-25岁），FEP样本（N = 39）和匹配的对照样本（N = 34）。我们提取了各个时间序列，并从大脑区域计算了相关性，然后将其平均分为4个年龄段：儿童晚期，青春期早期，青春期晚期，成年。使用多种分析方法，我们评估了4个年龄组的网络稳定性，比较了对照组和精神病谱青年之间的稳定性，并将FEP的组级网络组织与对照组进行了比较。我们探讨了认知或临床症状学的变异性是否与网络组织有关。结果在PNC和LUNA的4个年龄段中，网络组织稳定，这些年龄段通常为青年人和PNC精神病谱系青年。在所有年龄段，精神病谱系和典型的发展中青年都具有类似的功能网络组织。符合精神病完全标准的FNC青年和FEP中的网络组织完好无损。认知功能或临床症状的变化与精神病谱青年或FEP中的网络组织无关。