Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease,Trends in Endocrinology & Metabolism

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Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease
Trends in Endocrinology & Metabolism ( IF 11.4 ) Pub Date : 2019-11-01 , DOI: 10.1016/j.tem.2019.07.001
Luke Buntwal ₁ , Martina Sassi ₁ , Alwena H Morgan ₁ , Zane B Andrews ₂ , Jeffrey S Davies ₁

Affiliation

There is a close relationship between cognition and nutritional status, however, the mechanisms underlying this relationship require elucidation. The stomach hormone, ghrelin, which is released during food restriction, provides a link between circulating energy state and adaptive brain function. The maintenance of such homeostatic systems is essential for an organism to thrive and survive, and accumulating evidence points to ghrelin being key in promoting adult hippocampal neurogenesis and memory. Aberrant neurogenesis is linked to cognitive decline in ageing and neurodegeneration. Therefore, identifying endogenous metabolic factors that regulate new adult-born neurone formation is an important objective in understanding the link between nutritional status and central nervous system (CNS) function. Here, we review current developments in our understanding of ghrelin's role in regulating neurogenesis and memory function.

中文翻译：

Ghrelin 介导的海马神经发生：对健康和疾病的影响

认知和营养状况之间存在密切关系，然而，这种关系背后的机制需要阐明。在食物限制期间释放的胃激素生长素释放肽提供循环能量状态和适应性大脑功能之间的联系。维持这种稳态系统对于生物体的茁壮成长和生存至关重要，越来越多的证据表明生长素释放肽是促进成年海马神经发生和记忆的关键。异常的神经发生与衰老和神经退行性疾病的认知能力下降有关。因此，确定调节新成人出生神经元形成的内源性代谢因素是了解营养状况与中枢神经系统 (CNS) 功能之间联系的重要目标。这里，

更新日期：2019-11-01

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