The purpose of this study was to determine whether the enteric coating process affects growth performance, Fe bioavailability, and gene expression levels that maintain iron balance in the body. The test was divided into the control group, ferrous sulfate group, ferrous fumarate group, ferrous glycine chelate(1:1) (Fe-Gly(1:1)) group, ferrous glycine chelate(2:1) (Fe-Gly(2:1)) group, enteric-coated Fe-Gly(1:1) group, and enteric-coated Fe-Gly(2:1) group. The results showed that the growth performance of the rats in each iron supplement group was no significant difference among them. The results of serum biochemical indicators showed that the antioxidant capacity of the rats in the iron supplement group after enteric coating increased. The iron supplementation effect of Fe-Gly(1:1) and Fe-Gly(2:1) was better than that of ferrous sulfate, and the effect of Fe-Gly(1:1) after enteric coating was enhanced. The expression levels of IRP1 and IRP2 in the genes of enteric-coated Fe-Gly(1:1) and enteric-coated Fe-Gly(2:1) were significantly higher than those of ferrous sulfate. The expression levels of IRP1 and IRP2 in the protein of enteric-coated Fe-Gly(1:1) group were significantly higher than those in the Fe-Gly(1:1) group. The above results show that Fe-Gly can improve the bioavailability and antioxidant capacity of iron and reduce the iron output of feces after enteric coating.

中文翻译：

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不同铁源对SD大鼠铁生物利用度和体内稳态的影响。

这项研究的目的是确定肠溶衣过程是否影响生长性能，铁的生物利用度以及维持体内铁平衡的基因表达水平。该测试分为对照组，硫酸亚铁组，富马酸亚铁组，甘氨酸亚铁螯合物（1：1）（Fe-Gly（1：1））组，甘氨酸亚铁螯合物（2：1）（Fe-Gly（ 2：1））组，肠溶Fe-Gly（1：1）组和肠溶Fe-Gly（2：1）组。结果表明，每个铁补充剂组中大鼠的生长性能之间没有显着差异。血清生化指标的结果表明，肠溶包衣后，铁补铁组大鼠的抗氧化能力增强。Fe-Gly（1：1）和Fe-Gly（2：1）的补铁效果优于硫酸亚铁，增强了肠溶包衣后Fe-Gly（1：1）的效果。肠溶性Fe-Gly（1：1）和肠溶性Fe-Gly（2：1）基因中IRP1和IRP2的表达水平明显高于硫酸亚铁。肠溶Fe-Gly（1：1）组蛋白中IRP1和IRP2的表达水平明显高于Fe-Gly（1：1）组。以上结果表明，Fe-Gly可以提高肠溶衣后铁的生物利用度和抗氧化能力，并减少粪便中铁的输出。1）组明显高于Fe-Gly（1：1）组。以上结果表明，Fe-Gly可以提高肠溶衣后铁的生物利用度和抗氧化能力，并减少粪便中铁的输出。1）组明显高于Fe-Gly（1：1）组。以上结果表明，Fe-Gly可以提高肠溶衣后铁的生物利用度和抗氧化能力，并减少粪便中铁的输出。