In this issue of Immunity, Kimball et al. (2019) show that restoring expression of the chromatin modifying enzyme Setdb2 in macrophages rescues impaired wound healing associated with type 2 diabetes. Their findings reveal epigenetic regulation as central to the resolution of macrophage-mediated inflammation in tissue repair and have therapeutic implications for the treatment of diabetic wounds.

中文翻译：

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糖尿病阻碍巨噬细胞的表观遗传转换为修复模式

在本期《免疫》中，金博尔（Kimball）等 （2019）表明，恢复巨噬细胞中染色质修饰酶Setdb2的表达可以挽救与2型糖尿病相关的伤口愈合不良。他们的发现揭示了表观遗传调控是解决组织修复中巨噬细胞介导的炎症的关键，并且对糖尿病伤口的治疗具有治疗意义。