The interplay between intestinal epithelial barrier function, the intestinal microbiota, and cytokine signaling in the pathogenesis of inflammatory bowel disease is not completely understood. In this issue of Immunity, Eftychi et al. examined the cell types and cytokines that drive colitis in mice with an intestinal epithelial barrier defect and uncovered a surprising role for IL-12 in initiation of disease.

中文翻译：

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IL-12在IBD中到底有作用吗？

在炎症性肠病的发病机理中，肠上皮屏障功能，肠微生物群和细胞因子信号传导之间的相互作用尚不完全清楚。在《免疫》一期中，Eftychi等人 研究人员调查了具有肠上皮屏障缺损的小鼠中引起结肠炎的细胞类型和细胞因子，并揭示了IL-12在疾病引发中的令人惊讶的作用。