Nitric-Oxide-Releasing Biomaterial Regulation of the Stem Cell Microenvironment in Regenerative Medicine.,Advanced Materials

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Nitric-Oxide-Releasing Biomaterial Regulation of the Stem Cell Microenvironment in Regenerative Medicine.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-08-18 , DOI: 10.1002/adma.201805818
Adam C Midgley _{1,

2} , Yongzhen Wei ₂ , Zongjin Li ₂ , Deling Kong _{1,

2} , Qiang Zhao ₂

Affiliation

Stem cell therapy has proven to be an attractive solution for the treatment of degenerative diseases or injury. However, poor cell engraftment and survival within injured tissues limits the successful use of stem cell therapy within the clinical setting. Nitric oxide (NO) is an important signaling molecule involved in various physiological processes. Emerging evidence supports NO's diverse roles in modulating stem cell behavior, including survival, migration, differentiation, and paracrine secretion of proregenerative factors. Thus, there has been a shift in research focus to concentrate efforts on the delivery of therapeutic concentration ranges of NO to the target tissue sites. Combinatory therapies utilizing biomaterials that control NO generation and support stem cell delivery can be holistic and synergistic approaches to significantly improve tissue regeneration. Here, the focus is on recent developments of various therapeutic platforms, engineered to both transport NO and to enhance stem-cell-mediated regeneration of damaged tissues. New and emerging revelations of how the stem cell microenvironment can be regulated by NO-releasing biomaterials are also highlighted.

中文翻译：

再生医学中干细胞微环境释放一氧化氮的生物材料调控。

干细胞疗法已被证明是治疗退行性疾病或损伤的有吸引力的解决方案。但是，受损组织中的细胞植入不良和存活率低，限制了干细胞疗法在临床环境中的成功使用。一氧化氮（NO）是参与各种生理过程的重要信号分子。越来越多的证据支持NO在调节干细胞行为中的多种作用，包括存活，迁移，分化和前分泌因子的再生因子。因此，研究重点发生了转移，以集中精力将治疗浓度范围的NO输送到目标组织部位。利用控制NO生成并支持干细胞输送的生物材料的联合疗法可以是整体和协同的方法，可以显着改善组织的再生。在这里，重点是各种治疗平台的最新发展，这些平台设计用于转运NO和增强干细胞介导的受损组织的再生。还着重阐述了释放NO的生物材料如何调控干细胞微环境的新的和新兴的启示。

更新日期：2020-01-22

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