Glucose-Responsive Insulin and Delivery Systems: Innovation and Translation.,Advanced Materials

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Glucose-Responsive Insulin and Delivery Systems: Innovation and Translation.
Advanced Materials ( IF 27.4 ) Pub Date : 2019-08-18 , DOI: 10.1002/adma.201902004
Jinqiang Wang _{1,

2} , Zejun Wang _{1,

2} , Jicheng Yu ₃ , Anna R Kahkoska ₄ , John B Buse ₄ , Zhen Gu _{1,

2,

3,

5,

6}

Affiliation

Type 1 and advanced type 2 diabetes treatment involves daily injections or continuous infusion of exogenous insulin aimed at regulating blood glucose levels in the normoglycemic range. However, current options for insulin therapy are limited by the risk of hypoglycemia and are associated with suboptimal glycemic control outcomes. Therefore, a range of glucose-responsive components that can undergo changes in conformation or show alterations in intermolecular binding capability in response to glucose stimulation has been studied for ultimate integration into closed-loop insulin delivery or "smart insulin" systems. Here, an overview of the evolution and recent progress in the development of molecular approaches for glucose-responsive insulin delivery systems, a rapidly growing subfield of precision medicine, is presented. Three central glucose-responsive moieties, including glucose oxidase, phenylboronic acid, and glucose-binding molecules are examined in detail. Future opportunities and challenges regarding translation are also discussed.

中文翻译：

葡萄糖反应性胰岛素和输送系统：创新和转化。

1 型和晚期 2 型糖尿病的治疗包括每天注射或持续输注外源性胰岛素，旨在将血糖水平调节在正常血糖范围内。然而，目前胰岛素治疗的选择受到低血糖风险的限制，并且与血糖控制结果不佳有关。因此，已经研究了一系列可以响应葡萄糖刺激而发生构象变化或显示分子间结合能力改变的葡萄糖响应成分，以最终整合到闭环胰岛素递送或“智能胰岛素”系统中。本文概述了葡萄糖反应性胰岛素输送系统（精准医学的一个快速发展的子领域）的分子方法开发的演变和最新进展。详细检查了三个中心葡萄糖响应部分，包括葡萄糖氧化酶、苯基硼酸和葡萄糖结合分子。还讨论了翻译方面未来的机遇和挑战。

更新日期：2020-04-01

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