There is growing evidence that aryl organophosphate flame retardants (aryl-OPFRs) can disrupt lipid metabolism in animals. However, epidemiologic studies of this possible phenomenon are lacking. In this study, we explored the association between urinary concentrations of three aryl-OPFRs (triphenyl phosphate (TPHP), tricresyl phosphate, and 2-ethylhexyl diphenyl phosphate (EHDPP)) metabolites and plasma levels of triglyceride (TG) and total cholesterol (TC) in 259 samples of the general population by comparing with six alkylated and chlorinated OPFRs. Multivariate linear regression analyses clarified that the log-transformed TC levels appeared to increase linearly across the quartiles of 5-OH-EHDPP (p trend <0.001) and 4-OH-TPHP (p trend <0.001), with an increase of 42.2% (95% CI, 36.2% to 48.2%) and 28.4% (95% CI, 26.5% to 30.3%) for the highest versus lowest quartiles of 5-OH-EHDPP and 4-OH-TPHP, respectively. The TG level also appeared to increase linearly across the quartiles of 5-OH-EHDPP (p trend <0.001) and 4-OH-TPHP (p trend <0.001). The TG level in the highest quartile of 5-OH-EHDPP was 89.9% higher (95% CI, 84.6% to 95.2%) than that in the lowest quartile and 45.3% higher (95% CI, 40.1% to 50.7%) than that in the highest 4-OH-TPHP quartile. We for the first time found that human exposure to EHDPP and TPHP is associated with increases in human TC and TG levels.

中文翻译：

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芳基有机磷酸酯阻燃剂磷酸三苯酯和2-乙基己基二苯磷酸酯与人血甘油三酸酯和总胆固醇水平的关联

越来越多的证据表明，有机磷酸芳基阻燃剂（芳基-OPFR）可以破坏动物体内的脂质代谢。但是，缺乏对此可能现象的流行病学研究。在这项研究中，我们探讨了三种芳基-OPFR（磷酸三苯酯（TPHP），磷酸三甲苯酯和2-乙基己基磷酸二苯酯（EHDPP））代谢产物的尿浓度与血浆甘油三酸酯（TG）和总胆固醇（TC）之间的关系。 ），并与六个烷基化和氯化的OPFR进行比较，在259个普通人群的样本中进行了比较。多元线性回归分析表明，对数转换后的TC水平在5-OH-EHDPP（p趋势<0.001）和4-OH-TPHP（p趋势<0.001），最高和最低四分位数的5-OH-EHDPP和4分别增长42.2％（95％CI，36.2％至48.2％）和28.4％（95％CI，26.5％至30.3％） -OH-TPHP。TG水平在5-OH-EHDPP（p趋势<0.001）和4-OH-TPHP（p趋势<0.001）的四分位数中也呈线性增加。5-OH-EHDPP最高四分位数的TG水平比最低四分位数的TG高89.9％（95％CI，84.6％至95.2％），比最低四分位数高45.3％（95％CI，40.1％至50.7％）在最高的4-OH-TPHP四分位数中 我们首次发现人类暴露于EHDPP和TPHP与人类TC和TG水平升高有关。