Aortic stenosis is a heterogeneous disorder. Variations in the pathological and physiological responses to pressure overload are incompletely understood and generate a range of flow and pressure gradient patterns, which ultimately cause varying microvascular effects. The impact of cardiac-coronary coupling depends on these pressure and flow effects. In this article, we explore important concepts concerning cardiac physiology and the coronary microcirculation in aortic stenosis and their impact on myocardial remodeling, aortic valve flow patterns, and clinical progression.

中文翻译：

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主动脉瓣狭窄的冠状动脉微循环。

主动脉瓣狭窄是一种异质性疾病。对压力超负荷的病理和生理反应的变化尚不完全清楚，并产生一系列流量和压力梯度模式，最终导致不同的微血管效应。心脏-冠状动脉耦合的影响取决于这些压力和流量效应。在本文中，我们探讨了有关心脏生理学和主动脉瓣狭窄冠状动脉微循环的重要概念及其对心肌重塑、主动脉瓣血流模式和临床进展的影响。