Circadian rhythms are daily oscillations that, in mammals, are driven by both a master clock, located in the brain, and peripheral clocks in cells and tissues. Approximately 10% of the transcriptome, including extracellular matrix components, is estimated to be under circadian control. Whilst it has been established that certain collagens and extracellular matrix proteases are diurnally regulated (for example in tendon, cartilage and intervertebral disc) the role played by circadian rhythms in mediating elastic fiber homeostasis is poorly understood. Skin, arteries and lungs are dynamic, resilient, elastic fiber-rich organs and tissues. In skin, circadian rhythms influence cell migration and proliferation, wound healing and susceptibility of the tissues to damage (from protease activity, oxidative stress and ultraviolet radiation). In the cardiovascular system, blood pressure and heart rate also follow age-dependent circadian rhythms whilst the lungs exhibit diurnal variations in immune response. In order to better understand these processes it will be necessary to characterise diurnal changes in extracellular matrix biology. In particular, given the sensitivity of peripheral clocks to external factors, the timed delivery of interventions (chronotherapy) has the potential to significantly improve the efficacy of treatments designed to repair and regenerate damaged cutaneous, vascular and pulmonary tissues.

中文翻译：

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皮肤和其他弹性组织中的昼夜节律。

在哺乳动物中，昼夜节律是每天的振荡，由位于大脑中的主时钟以及细胞和组织中的外围时钟驱动。估计大约有10％的转录组（包括细胞外基质成分）处于昼夜节律控制下。尽管已经确定某些胶原蛋白和细胞外基质蛋白酶是昼夜调节的（例如在肌腱，软骨和椎间盘中），但昼夜节律在介导弹性纤维稳态方面的作用尚不清楚。皮肤，动脉和肺是充满活力，有弹性，富有弹性的富含纤维的器官和组织。在皮肤中，昼夜节律会影响细胞迁移和增殖，伤口愈合以及组织对损伤的敏感性（来自蛋白酶活性，氧化应激和紫外线辐射）。在心血管系统中，血压和心率也遵循年龄相关的昼夜节律，而肺部的免疫反应则表现为昼夜变化。为了更好地理解这些过程，有必要表征细胞外基质生物学的昼夜变化。特别是，考虑到外围时钟对外部因素的敏感性，及时的干预措施（计时疗法）有可能显着提高旨在修复和再生受损的皮肤，血管和肺组织的治疗功效。为了更好地理解这些过程，有必要表征细胞外基质生物学的昼夜变化。特别是，考虑到外围时钟对外部因素的敏感性，及时的干预措施（计时疗法）有可能显着提高旨在修复和再生受损的皮肤，血管和肺组织的治疗功效。为了更好地理解这些过程，有必要表征细胞外基质生物学的昼夜变化。特别是，考虑到外围时钟对外部因素的敏感性，及时的干预措施（计时疗法）有可能显着提高旨在修复和再生受损的皮肤，血管和肺组织的治疗功效。