Bariatric surgery is currently the most effective therapeutic modality through which sustained beneficial effects on weight loss and metabolic improvement are achieved. During recent years, indications for bariatric surgery have been expanded to include cases of poorly controlled type 2 (T2DM) diabetes mellitus in lesser extremes of body weight. A spectrum of the beneficial effects of surgery is attributed to robust changes of postprandial gut peptide responses that are observed post operatively. Consolidated knowledge regarding gut peptide physiology as well as emerging new evidence shedding light on the mode of action of previously overlooked gut hormones provide appealing potential obesity and T2DM therapeutic perspectives. The accumulation of evidence from the effect of exogenous administration of native gut peptides alone or in combinations to humans as well as the development of mimetic agents exerting agonistic effects on combinations of gut hormone receptors pave the way for future integrated gut peptide-based treatments, which may mimic the effects of bariatric surgery.

中文翻译：

---

模仿肠道激素或靶向其受体的药物会最终取代减肥手术吗？

减肥手术是目前最有效的治疗方法，通过该方法可实现对体重减轻和代谢改善的持续有益作用。近年来，减肥手术的适应症已扩大到包括体重较轻的极端情况下控制不佳的2型（T2DM）糖尿病病例。手术的有益效果的频谱归因于术后观察到的餐后肠肽反应的强烈变化。有关肠肽生理学的综合知识以及新兴的新证据揭示了先前被忽视的肠激素的作用方式，提供了诱人的潜在肥胖症和T2DM治疗的观点。