Carefully regulated lipid homeostastis generates an optimal physiological, non-toxic environment. Imbalances in lipid metabolism lead to obesity and are associated with type-2 diabetes, hepatic steatosis, hypertension and cardiovascular disease. Mammals store energy in lipid droplets predominantly in white adipose tissue. This energy reservoir builds up during periods of energy excess and is mobilized during energy deprivation. Triacylglycerols (TAGs) are unable to cross cell membranes for cell nutrition; they have to be cleaved before further transportation within the body. Lipolysis describes the cleavage of TAG and is carried out with the help of lipases. Adipose triglyceride lipase (ATGL) catalyzes the first step of intracellular lipolysis to mobilize TAG stores. In this minireview, we set the focus on molecular mechanism and interfaces behind co-activation and inhibition of ATGL, namely via its regulation by the co-activating protein CGI-58, the inhibitory proteins G0S2 and HILPDA, as well as the regulatory effect of fatty acid binding proteins and the perilipin protein family.

中文翻译：

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蛋白-蛋白相互作用调节细胞内脂解中的甘油三酸酯脂肪酶的活性。

精心调节的脂质动态平衡可产生最佳的生理无毒环境。脂质代谢失衡会导致肥胖，并与2型糖尿病，肝脂肪变性，高血压和心血管疾病有关。哺乳动物主要在白色脂肪组织中的脂滴中存储能量。该能量储存器在能量过剩期间建立，并在能量匮乏时动员。三酰基甘油（TAG）无法穿过细胞膜来获得细胞营养；在体内进一步运输之前，必须先将其裂解。脂解作用描述了TAG的裂解，并在脂肪酶的帮助下进行。甘油三酸酯脂肪酶（ATGL）催化细胞内脂解的第一步，以动员TAG储存。在这份迷你评论中，