Photodynamic therapy is a promising approach for cancer treatment that relies on the administration of a photosensitizer followed by tumor illumination. The generated oxidative stress may activate multiple mechanisms of cell death which are counteracted by cells through adaptive stress responses that target homeostasis rescue. The present renaissance of PDT was leveraged by the acknowledgment that this therapy has an immediate impact locally, in the illumination volume, but that subsequently it may also elicit immune responses with systemic impact. The investigation of the mechanisms of cell death under the oxidative stress of PDT is of paramount importance to understand how the immune system is activated and, ultimately, to make PDT a more appealing/relevant therapeutic option.

光动力疗法是一种有前途的癌症治疗方法，它依赖于光敏剂的施用，然后进行肿瘤照射。产生的氧化应激可能激活细胞死亡的多种机制，这些机制可以通过针对稳态的适应性应激反应而被细胞抵消。认识到PDT的复兴，是因为这种疗法在光照量方面局部产生了直接的影响，但随后它也可能引发全身性的免疫反应。研究PDT氧化应激下的细胞死亡机制对于了解免疫系统如何激活以及最终使PDT成为更具吸引力/相关的治疗选择至关重要。