Polyoxomolybdate (POM) nanoclusters with radiosensitizing and scintillating properties for low dose X-ray inducible radiation-radiodynamic therapy†,Nanoscale Horizons

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Polyoxomolybdate (POM) nanoclusters with radiosensitizing and scintillating properties for low dose X-ray inducible radiation-radiodynamic therapy†
Nanoscale Horizons ( IF 8.0 ) Pub Date : 2019-08-07 , DOI: 10.1039/c9nh00374f
Debabrata Maiti _{1,

2,

3,

4,

5} , Jing Zhong _{1,

2,

3,

4,

5} , Zheng Zhang _{1,

2,

3,

4,

5} , Hailin Zhou _{1,

2,

3,

4,

5} , Saisai Xion _{1,

2,

3,

4,

5} , Ziliang Dong _{4,

5,

6,

7} , Sarvendra Kumar _{4,

5,

6,

7} , Zhuang Liu _{4,

5,

6,

7} , Kai Yang _{1,

2,

3,

4,

5}

Affiliation

In order to overcome the weak penetration of near infrared (NIR) light in photodynamic therapy (PDT), X-ray radiation (X-RT) with high deep tissue penetration could be used as a therapeutic option to completely destroy tumors. Herein, polyoxomolybdate nanoclusters (POMo NCs) with rose Bengal (RB) loading, are functionalized with chitosan (CS) and polyethylene glycol (PEG) for X-ray inducible radiation and radiodynamic therapy (X-RRDT). Our obtained POMo NCs demonstrate a strawberry shape containing 163 Mo (Mo)3 units of three edge sharing MoO₆ octahedra and connecting to the central PO₄ octahedron. Under low dose X-ray radiation, the communal effect of radiosensitization and scintillation of POMo NCs along with RB, can decrease the side effects of RT and enhance both RT and PDT efficiency. This is because the POMo NCs can not only augment RT efficacy by producing auger electrons which directly provoke DNA damage, but also enhance PDT efficacy by converting high energy X-rays into light to stimulate RB to generate singlet oxygen (¹O₂). In vivo results show that X-RRDT using POMo NCs significantly inhibits tumor growth under low dose X-ray radiation. More importantly, the as-made PEGylated POMo NCs cause no obvious side-effects to the major normal organs through histological examination. This work describes a simple strategy to design effective X-RRDT agents with multiple properties including X-ray radiosensitization, X-ray scintillation and photosensitization for X-RRDT under low dose X-ray irradiation. Our developed strategy will further promote the cancer therapeutic efficiency under low dose X-ray radiation, and bring hope for clinical cancer treatment.

中文翻译：

具有放射增敏和闪烁特性的聚氧钼酸根（POM）纳米团簇，用于低剂量X射线诱导辐射-放射动力疗法†

为了克服光动力疗法（PDT）中近红外（NIR）光的弱穿透性，具有高深层组织穿透性的X射线辐射（X-RT）可以用作完全消灭肿瘤的治疗选择。在这里，具有玫瑰孟加拉（RB）负载的聚氧钼钼纳米簇（POMo NCs）用壳聚糖（CS）和聚乙二醇（PEG）进行功能化，以进行X射线诱导辐射和放射动力疗法（X-RRDT）。我们获得的POMo NC显示出草莓形状，其中包含163个Mo（Mo）3单元，三个边缘共享MoO ₆八面体，并连接到中心PO ₄八面体。在低剂量X射线辐射下，POMo NCs与RB一起的放射增敏和闪烁的共同作用可以减少RT的副作用，并提高RT和PDT的效率。这是因为POMo NCs不仅可以通过产生直接引起DNA损伤的螺旋电子来增强RT功效，而且还可以通过将高能X射线转换为光以刺激RB产生单线态氧（¹ O ₂）来增强PDT功效。体内结果表明，在低剂量X射线辐射下，使用POMo NC的X-RRDT可以显着抑制肿瘤的生长。更重要的是，通过组织学检查，制成的PEG化POMo NCs对主要正常器官没有明显的副作用。这项工作描述了一种简单的策略，以设计具有多种特性的有效X-RRDT试剂，包括在低剂量X射线照射下X-RRDT的X射线放射增敏，X射线闪烁和光敏性。我们制定的策略将进一步提高低剂量X射线辐射下的癌症治疗效率，并为临床癌症治疗带来希望。

更新日期：2019-12-17

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