A combination of chemotherapy and photothermal therapy (PTT) against cancer, overcoming the intrinsic limitations of single-modal chemotherapy or PTT, has emerged as a promising strategy to achieve synergistic therapeutic effect. However, the lack of precise drug delivery and intelligent drug release based on photo-chemotherapy at specific tumor sites remained a challenge. Hence, the both tumor-specific targeting molecule (methotrexate) and ligand (hyaluronic acid)-introduced, glutathione-responsive amphiphiles (deoxycholic acid-hyaluronic acid-methotrexate, DA-SS-HA-MTX) were developed for synchronous delivery of indocyanine green (ICG) and doxorubicin (DOX). The as-synthesized DOX/[email protected] remarkably improved the intracellular drug uptake and accumulation owing to both the CD44/folate receptors-mediated synergistic targeting and the glutathione-triggered rapid drug release. Moreover, DOX/[email protected] efficiently accumulated at the tumor sites, realizing the notable tumor ablation under the guidance of dual-modal optical imaging. Taken together, this study provided a promising nanotheranostic agent for imaging-guided chemo-photothermal combination therapy.

克服单模式化学疗法或PTT的固有局限性的化学疗法和抗癌光热疗法（PTT）的组合已成为实现协同治疗效果的一种有前途的策略。然而，在特定肿瘤部位缺乏基于光化学疗法的精确药物递送和智能药物释放仍然是一个挑战。因此，开发了肿瘤特异性靶向分子（甲氨蝶呤）和配体（透明质酸）引入的谷胱甘肽反应性两亲物（脱氧胆酸-透明质酸-甲氨蝶呤，DA-SS-HA-MTX），用于吲哚菁绿的同步递送。 （ICG）和阿霉素（DOX）。由于CD44 /叶酸受体介导的协同靶向作用和谷胱甘肽触发的快速药物释放，合成后的DOX / [电子邮件保护]显着改善了细胞内药物的吸收和积累。而且，DOX / [电子邮件保护]有效地积聚在肿瘤部位，在双模态光学成像的指导下实现了显着的肿瘤消融。综上所述，这项研究为成像引导的化学-光热联合疗法提供了一种有前途的纳米治疗剂。