Fe3O4–Pd Janus nanoparticles with amplified dual-mode hyperthermia and enhanced ROS generation for breast cancer treatment†,Nanoscale Horizons

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Fe3O4–Pd Janus nanoparticles with amplified dual-mode hyperthermia and enhanced ROS generation for breast cancer treatment†
Nanoscale Horizons ( IF 8.0 ) Pub Date : 2019-08-02 , DOI: 10.1039/c9nh00233b
Xiaowei Ma _{1,

2,

3,

4,

5} , Yanyun Wang _{1,

2,

3,

4,

5} , Xiao-Li Liu _{1,

2,

3,

4,

5} , Huijun Ma _{1,

2,

3,

4,

5} , Galong Li _{1,

2,

3,

4,

5} , Yao Li _{5,

6,

7,

8,

9} , Fei Gao _{1,

2,

3,

4,

5} , Mingli Peng _{1,

2,

3,

4,

5} , Hai Ming Fan _{1,

2,

3,

4,

5} , Xing-Jie Liang _{5,

6,

7,

8,

9}

Affiliation

Developing multifunctional theranostic nanoplatforms with high tumor therapeutic efficacy is the focus area of nanomedicine. In this study, we have designed Fe₃O₄–Pd Janus nanoparticles (JNPs) with dual-mode magnetic resonance imaging/photoacoustic (MRI/PA) imaging properties for magnetic-photo hyperthermia and chemodynamic therapy simultaneously. Due to the magnetic-photothermal properties of Fe₃O₄ nanoparticles and plasmonic photothermia effect of Pd nanosheets, the combined Fe₃O₄–Pd JNPs can achieve synergistic heating effects of 1 + 1 > 2. It is demonstrated that Fe₃O₄–Pd JNPs reached a higher temperature enhancement under alternating magnetic field (AMF) plus laser irradiation than the corresponding individual modality (only AMF or laser irradiation alone for Fe₃O₄–Pd JNPs) or the sum of two individual modalities. Besides amplified magnetic-photo heating, Fe₃O₄–Pd JNPs also enhanced ROS generation due to the interface synergistic effect in producing hydroxyl radicals (˙OH), which is realized by Fe₃O₄ nanoparticle-based Fenton reaction and Pd nanosheet-based catalytic properties in the presence of H₂O₂ in an acidic environment. Remarkably, the ROS level could be further elevated under external AMF plus laser irradiation. The in vivo anti-tumor effect of Fe₃O₄–Pd JNPs was evaluated on a 4T1 orthotopic mouse breast cancer model. The results showed that Fe₃O₄–Pd JNPs enable complete tumor inhibition without appreciable adverse effects under AMF plus laser irradiation, guided by MRI/PA dual-mode imaging with a high spatial resolution and accuracy. This study provides an alternative way for cancer therapy by on-demand design of high-performance theranostic nanoplatforms according to the characteristics of the tumor microenvironment and the intriguing physiochemical properties of inorganic nanomaterials.

中文翻译：

Fe ₃ O ₄ -Pd Janus纳米粒子具有放大的双模式热疗和增强的ROS生成，可用于乳腺癌治疗†

开发具有高肿瘤治疗功效的多功能治疗药物纳米平台是纳米医学的重点领域。在这项研究中，我们设计了具有双模式磁共振成像/光声（MRI / PA）成像特性的Fe ₃ O ₄ -Pd Janus纳米颗粒（JNPs），用于同时进行磁光热疗和化学动力学治疗。由于Fe ₃ O ₄纳米粒子的磁光热性质和Pd纳米片的等离子光热效应，Fe ₃ O ₄ -Pd JNPs的组合可实现1 + 1> 2的协同加热作用。证明了Fe ₃ O ₄–Pd JNP在交变磁场（AMF）加上激光辐照下比相应的单个模态（Fe ₃ O ₄ –Pd JNP仅AMF或单独的激光辐照）或两个单独模态的总和达到更高的温度增强。Fe ₃ O ₄ -Pd JNP除了放大的磁光加热外，由于在产生羟基自由基（˙OH）方面的界面协同作用，还增强了ROS的产生，这是通过基于Fe ₃ O ₄纳米粒子的Fenton反应和Pd纳米片实现的。 H ₂ O ₂存在下的基于碱的催化性能在酸性环境中。值得注意的是，在外部AMF加激光照射下，ROS水平可能会进一步升高。的体内铁的抗肿瘤效果₃ ö ₄ -Pd JNPs物上的4T1原位小鼠乳腺癌模型评估。结果表明，在MRI / PA双模成像的指导下，具有高空间分辨率和准确性的Fe ₃ O ₄ -Pd JNPs能够在AMF加激光辐照下完全抑制肿瘤，而没有明显的不良影响。这项研究根据肿瘤微环境的特征和无机纳米材料有趣的理化特性，通过按需设计高性能的治疗性纳米平台，为癌症治疗提供了另一种方法。

更新日期：2019-10-21

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